Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population.

Détails

ID Serval
serval:BIB_255C35EB7D7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population.
Périodique
Journal of Neurology, Neurosurgery, and Psychiatry
Auteur(s)
Martino D., Draganski B., Cavanna A., Church A., Defazio G., Robertson M.M., Frackowiak R.S., Giovannoni G., Critchley H.D.
ISSN
1468-330X (Electronic)
ISSN-L
0022-3050
Statut éditorial
Publié
Date de publication
2008
Volume
79
Numéro
7
Pages
820-822
Langue
anglais
Résumé
Anti-basal ganglia antibodies (ABGAs) have been suggested to be a hallmark of autoimmunity in Gilles de la Tourette's syndrome (GTS), possibly related to prior exposure to streptococcal infection. In order to detect whether the presence of ABGAs was associated with subtle structural changes in GTS, whole-brain analysis using independent sets of T(1) and diffusion tensor imaging MRI-based methods were performed on 22 adults with GTS with (n = 9) and without (n = 13) detectable ABGAs in the serum. Voxel-based morphometry analysis failed to detect any significant difference in grey matter density between ABGA-positive and ABGA-negative groups in caudate nuclei, putamina, thalami and frontal lobes. These results suggest that ABGA synthesis is not related to structural changes in grey and white matter (detectable with these methods) within frontostriatal circuits.
Mots-clé
Adolescent, Adult, Anisotropy, Autoantibodies/blood, Basal Ganglia/immunology, Basal Ganglia/pathology, Case-Control Studies, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Severity of Illness Index, Thalamus/pathology, Tourette Syndrome/blood, Tourette Syndrome/immunology
Pubmed
Web of science
Création de la notice
02/09/2011 19:59
Dernière modification de la notice
20/08/2019 14:03
Données d'usage