End points for new agents in induction chemotherapy for locally advanced head and neck cancers.

Détails

ID Serval
serval:BIB_25402
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
End points for new agents in induction chemotherapy for locally advanced head and neck cancers.
Périodique
Annals of Oncology
Auteur(s)
Monnerat C., Faivre S., Temam S., Bourhis J., Raymond E.
ISSN
0923-7534
Statut éditorial
Publié
Date de publication
2002
Volume
13
Numéro
7
Pages
995-1006
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
More than 60% of patients diagnosed with squamous cell carcinoma of the head and neck present at a locally advanced stage. Although multimodality therapy has improved locoregional control, the 5-year survival rate of this population rarely exceeds 30%. In this review, we analyzed the impact of chemotherapy in the management of locally advanced head and neck cancer and we underline the potential benefit of induction chemotherapy. The Meta-Analysis of Chemotherapy in Head and Neck Cancer collaborative group has suggested a survival advantage of 5% at 5 years for platin-5-fluorouracil induction chemotherapy. We have analyzed cofactors that may affect the survival of head and neck patients and propose new end points for assessment of the efficacy of induction chemotherapy. The detrimental effect of second primary tumors on long-term results is stressed and we have suggested the use of overall 2-year survival as a surrogate end point for induction chemotherapy efficacy. Finally, we have examined the impact of new cytotoxic agents and present the promising results of new taxane-based combinations.
Mots-clé
Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Biopsy, Needle, Carcinoma, Squamous Cell/drug therapy, Carcinoma, Squamous Cell/mortality, Female, Follow-Up Studies, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/mortality, Humans, Male, Neoplasm Metastasis, Neoplasm Staging, Paclitaxel/administration & dosage, Paclitaxel/analogs & derivatives, Randomized Controlled Trials as Topic, Remission Induction, Survival Analysis, Taxoids, Treatment Outcome
Pubmed
Web of science
Création de la notice
19/11/2007 13:21
Dernière modification de la notice
20/08/2019 14:03
Données d'usage