Clinical experience with Timentin in severe hospital infections.

Détails

ID Serval
serval:BIB_24CFD302E9D4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical experience with Timentin in severe hospital infections.
Périodique
Journal of Antimicrobial Chemotherapy
Auteur⸱e⸱s
Meylan P.R., Calandra T., Casey P.A., Glauser M.P.
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Statut éditorial
Publié
Date de publication
05/1986
Peer-reviewed
Oui
Volume
17 Suppl C
Pages
127-139
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Sixty-four severe infections in hospitalized patients were treated with intravenous Timentin. Most patients (mean age: 50.5 years, range 18-85) had serious underlying conditions such as agranulocytosis, heart failure, cancer, diabetes mellitus, chronic alcoholism or other functional or anatomical abnormalities. Forty-three episodes were bacteriologically proved, and bacteraemia was diagnosed in 18. The sites of infection were: lower respiratory tract (10), upper respiratory tract (10), soft tissues (9), urinary tract (7), bones (6), peritoneal cavity (3), meninges (1) and pelvis (1). In addition, 13 episodes of fever and four of septicaemia in patients with agranulocytosis were treated with Timentin plus amikacin. Overall, 59% of the episodes were cured, 14% improved and 17% failed to respond. In 9% of cases the efficacy of the Timentin was unassessable mainly because of concurrent administration of other antimicrobials. Failure appeared to be more frequent in soft tissue and intra-abdominal infections, in patients infected with bacteria susceptible to Timentin but resistant to ticarcillin and in patients superinfected with Timentin-resistant strains. Major side effects were haemorrhagic diathesis with platelet dysfunction (1), severe water sodium overload (1), and possibly pancreatitis (1). Other side effects were mild: catheter-related phlebitis, and abnormal but clinically insignificant laboratory test results. Timentin appears to be an effective and safe broad-spectrum combination which compares favourably with third-generation cephalosporins in the treatment of severe hospital infections. More experience is needed to decide whether the somewhat lower response rate in patients infected with ticarcillin-resistant strains is significant.
Mots-clé
Acute Disease, Adolescent, Adult, Aged, Amikacin/administration & dosage, Amikacin/therapeutic use, Bacteria/drug effects, Bacteria/isolation & purification, Bacterial Infections/complications, Bacterial Infections/drug therapy, Clavulanic Acids/administration & dosage, Clavulanic Acids/adverse effects, Cross Infection/complications, Cross Infection/drug therapy, Drug Combinations/administration & dosage, Drug Combinations/adverse effects, Drug Evaluation, Drug Therapy, Combination, Female, Hemorrhagic Disorders/chemically induced, Humans, Male, Middle Aged, Pancreatitis/chemically induced, Penicillin Resistance, Penicillins/therapeutic use, Ticarcillin/administration & dosage, Ticarcillin/adverse effects
Pubmed
Web of science
Création de la notice
25/01/2008 13:28
Dernière modification de la notice
20/08/2019 13:03
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