Test methods: anabolics.

Détails

ID Serval
serval:BIB_24CBE7259614
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Test methods: anabolics.
Périodique
Baillière's Best Practice and Research. Clinical Endocrinology and Metabolism
Auteur(s)
Saugy M., Cardis C., Robinson N., Schweizer C.
Statut éditorial
Publié
Date de publication
2000
Volume
14
Numéro
1
Pages
111-133
Langue
anglais
Résumé
In the International Olympic Committee (IOC) accredited laboratories, specific methods have been developed to detect anabolic steroids in athletes' urine. The technique of choice to achieve this is gas-chromatography coupled with mass spectrometry (GC-MS). In order to improve the efficiency of anti-doping programmes, the laboratories have defined new analytical strategies. The final sensitivity of the analytical procedure can be improved by choosing new technologies for use in detection, such as tandem mass spectrometry (MS-MS) or high resolution mass spectrometry (HRMS). A better sample preparation using immuno-affinity chromatography (IAC) is also a good tool for improving sensitivity. These techniques are suitable for the detection of synthetic anabolic steroids whose structure is not found naturally in the human body. The more and more evident use, on a large scale, of substances chemically similar to the endogenous steroids obliges both the laboratory and the sports authorities to use the steroid profile of the athlete in comparison with reference ranges from a population or with intraindividual reference values.
Mots-clé
Anabolic Agents, Chromatography, Affinity, Doping in Sports, Gas Chromatography-Mass Spectrometry, Humans, Mass Spectrometry, Sensitivity and Specificity, Substance Abuse Detection
Pubmed
Web of science
Création de la notice
28/03/2009 12:28
Dernière modification de la notice
20/08/2019 13:03
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