Rationale and design of the prospective German registry of outcome in patients with severe disorders of consciousness after acute brain injury

Détails

ID Serval
serval:BIB_24C00DC3D7C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Rationale and design of the prospective German registry of outcome in patients with severe disorders of consciousness after acute brain injury
Périodique
Arch Phys Med Rehabil
Auteur⸱e⸱s
Grill E., Klein A. M., Howell K., Arndt M., Bodrozic L., Herzog J., Jox R., Koenig E., Mansmann U., Muller F., Muller T., Nowak D., Schaupp M., Straube A., Bender A.
ISSN
1532-821X (Electronic)
ISSN-L
0003-9993
Statut éditorial
Publié
Date de publication
10/2013
Volume
94
Numéro
10
Pages
1870-6
Langue
anglais
Notes
Grill, Eva
Klein, Anke-Maria
Howell, Kaitlen
Arndt, Marion
Bodrozic, Lydia
Herzog, Jurgen
Jox, Ralf
Koenig, Eberhardt
Mansmann, Ulrich
Muller, Friedemann
Muller, Thomas
Nowak, Dennis
Schaupp, Matthias
Straube, Andreas
Bender, Andreas
eng
Multicenter Study
Research Support, Non-U.S. Gov't
2013/06/05 06:00
Arch Phys Med Rehabil. 2013 Oct;94(10):1870-6. doi: 10.1016/j.apmr.2012.10.040. Epub 2013 May 31.
Résumé
OBJECTIVE: To describe the rationale and design of a new patient registry (Koma Outcome von Patienten der Fruhrehabilitation-Register [KOPF-R; Registry for Coma Outcome in Patients Undergoing Acute Rehabilitation]) that has the scope to examine determinants of long-term outcome and functioning of patients with severe disorders of consciousness (DOC). DESIGN: Prospective multicenter neurologic rehabilitation registry. SETTING: Five specialized neurologic rehabilitation facilities. PARTICIPANTS: Patients (N=42) with DOC in vegetative state or minimally conscious state (MCS) as defined by the Coma Recovery Scale-Revised (CRS-R) after brain injury. Patients are being continuously enrolled. The data presented here cover the enrollment period from August 2011 to January 2012. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: CRS-R, FIM, and emergence from MCS. RESULTS: The registry was set up in 5 facilities across the state of Bavaria/Germany with a special expertise in the rehabilitation of acquired brain injury. Inclusion of patients started in August 2011. Measures include sociodemographic and clinical characteristics, course of acute therapy, electrophysiologic measures (evoked potentials, electroencephalogram), neuron-specific enolase, current medication, functioning, cognition, participation, quality of life, quantity and characteristics of rehabilitation therapy, caregiver burden, and attitudes toward end-of-life decisions. Main diagnoses were traumatic brain injury (24%), intracerebral or subarachnoid hemorrhage (31%), and anoxic-ischemic encephalopathy (45%). Mean CRS-R score +/- SD at admission to rehabilitation was 5.9 +/- 3.3, and mean FIM score +/- SD at admission was 18 +/- 0.4. CONCLUSIONS: The KOPF-R aspires to contribute prospective data on prognosis in severe DOC.
Mots-clé
Acute Disease, Adult, Aged, Brain Injuries/*complications/mortality, Cognition, Data Collection, Female, Germany, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Persistent Vegetative State/*etiology/*rehabilitation, Prospective Studies, Quality of Life, Recovery of Function, *Registries, Rehabilitation Centers, Treatment Outcome, Aie, Anoxia, Brain injuries, Ci, Crs-r, Coma Recovery Scale-Revised, Doc, Disability evaluation, Eeg, Icu, Kopf-r, Koma Outcome von Patienten der Fruhrehabilitation- Register [Registry for Coma, Outcome in Patients Undergoing Acute Rehabilitation], Lst, Mcs, Nse, Ntbi, Persistent vegetative state, Qol, Registries, Rehabilitation, Sah, SEPs, Tbi, Vs, anoxic-ischemic encephalopathy, confidence interval, disorders of consciousness, electroencephalogram, intensive care unit, life-sustaining therapy, minimally conscious state, neuron-specific enolase, nontraumatic brain injury, somatosensory evoked potentials, subarachnoid hemorrhage, traumatic brain injury, vegetative state
Pubmed
Création de la notice
14/07/2017 10:09
Dernière modification de la notice
20/08/2019 14:03
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