Increased circulating placental growth factor during percutaneous coronary intervention is associated with applied radiocontrast agent.

Détails

ID Serval
serval:BIB_249E1937246B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Increased circulating placental growth factor during percutaneous coronary intervention is associated with applied radiocontrast agent.
Périodique
Coronary artery disease
Auteur⸱e⸱s
Steppich B.A., Kaufmann J., Sepp D., Kunert K., Rutz T., Stratz C., Ott I.
ISSN
1473-5830 (Electronic)
ISSN-L
0954-6928
Statut éditorial
Publié
Date de publication
03/2009
Peer-reviewed
Oui
Volume
20
Numéro
2
Pages
130-137
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Recent studies have suggested placental growth factor (PlGF) and vascular endothelial growth factor (VEGF) as promising new biomarkers for risk stratification in acute coronary syndromes (ACS). However, little is known about the influence of percutaneous coronary intervention (PCI) on circulating PlGF and VEGF levels.
Thirty-five patients with ACS, 27 patients with stable coronary artery disease (sCAD), and nine healthy controls were enrolled in the study. Although all patients with ACS and 14 patients with stable angina pectoris underwent PCI, 13 patients with coronary artery disease required no revascularization (sCAD). PlGF and VEGF plasma concentrations were measured by immunoassay during and at the end of PCI and coronary angiography.
Plasma PlGF levels were comparable in patients with ACS and sCAD on admission. Although coronary angiography or heparin alone did not alter PlGF and VEGF levels, immediately after PCI a dramatic increase was seen in circulating PlGF and a decrease in VEGF, which was independent of the clinical presentation of the patients, heparin administration, or the angiographic procedure itself, but was associated with the extent of coronary artery disease and the amount of the injected contrast media. In-vitro experiments revealed that radiocontrast agents induced the release of PlGF from endothelial cells without altering PlGF mRNA expression.
Patients undergoing PCI exhibit an increase in circulating PlGF, probably caused by posttranslational modifications of radiocontrast agents in endothelial cells. Therefore, analysis of plasma PlGF and VEGF levels may consider the timing of blood sampling with respect to PCI and contrast media exposure.

Mots-clé
Angina Pectoris/blood, Angina Pectoris/etiology, Angina Pectoris/therapy, Angioplasty, Balloon, Coronary, Anticoagulants/therapeutic use, Biomarkers/blood, Case-Control Studies, Cells, Cultured, Contrast Media/adverse effects, Coronary Angiography, Coronary Stenosis/blood, Coronary Stenosis/complications, Coronary Stenosis/diagnostic imaging, Coronary Stenosis/therapy, Dose-Response Relationship, Drug, Endothelial Cells/drug effects, Endothelial Cells/metabolism, Heparin/therapeutic use, Humans, Interleukin-6/blood, Iopamidol/adverse effects, Iopamidol/analogs & derivatives, Myocardial Infarction/blood, Myocardial Infarction/diagnostic imaging, Myocardial Infarction/etiology, Myocardial Infarction/therapy, Placenta Growth Factor, Pregnancy Proteins/blood, Severity of Illness Index, Time Factors, Treatment Outcome, Triiodobenzoic Acids/adverse effects, Up-Regulation, Vascular Endothelial Growth Factor A/blood
Pubmed
Web of science
Création de la notice
07/08/2017 11:24
Dernière modification de la notice
20/08/2019 13:02
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