The effect of locoregional recurrence on survival and distant metastasis after conservative treatment for invasive breast carcinoma

Détails

ID Serval
serval:BIB_248FE76A15C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The effect of locoregional recurrence on survival and distant metastasis after conservative treatment for invasive breast carcinoma
Périodique
Clinical Oncology (royal College of Radiologists (great Britain))
Auteur(s)
Monteiro Grillo I., Jorge M., Marques Vidal P., Ortiz M., Ravasco P.
ISSN
0936-6555 (Print)
ISSN-L
0936-6555
Statut éditorial
Publié
Date de publication
2005
Volume
17
Numéro
2
Pages
111-117
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
AIMS: Patients with invasive breast cancer submitted to conservative treatment must be followed for a long period of time to study locoregional control. In this study, we analysed the outcome and relationships between locoregional recurrence (LRR), distant metastases and survival.
MATERIALS AND METHODS: A 15-year study, including 470 women with early breast cancer, stage I and II, who underwent breast conservative treatment. Tumour size, nodal status, age, menopausal status, histological grade and LRR were analysed for their ability to predict overall survival, disease-specific survival and distant disease-free survival.
RESULTS: With a median follow-up time of 6.6 years (3 months to 19.1 years), there were 19 LRR at their first site of recurrence and 53 distant metastases. Tumour size greater than 2 cm, positive lymph nodes and histological grade III were significantly related to lower overall and distant metastases-free survival. On multivariate analysis, nodal status, histological grade III and LRR (coded as a time-dependent variable) were significantly related to overall, specific and distant metastases-free survival, whereas tumour size had only a borderline effect on specific and distant disease-free survival. Landmark analysis showed that women who presented an LRR within 2 years after surgery had significantly lower distant disease-free survival (hazard ratio [HR]: 8.39; 95% CI 2.56-27.47; P < 0.001), specific survival (HR: 8.19; 95% CI 2.45-27.41; P < 0.001) and overall survival (HR: 6.02; 95% CI 2.25-16.11; P < 0.005).
CONCLUSIONS: LRR seems to be a significant predictor of distant metastases and survival, and patients who sustain early LRR tend to display a more aggressive clinical course.
Mots-clé
Breast Neoplasms/mortality, Breast Neoplasms/pathology, Breast Neoplasms/therapy, Carcinoma, Ductal, Breast/mortality, Carcinoma, Ductal, Breast/secondary, Carcinoma, Ductal, Breast/therapy
Pubmed
Création de la notice
01/12/2016 16:01
Dernière modification de la notice
22/07/2020 6:26
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