Resolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.

Détails

ID Serval
serval:BIB_246B15679972
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Resolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.
Périodique
Journal of Magnetic Resonance
Auteur(s)
Gruetter R., Weisdorf S.A., Rajanayagan V., Terpstra M., Merkle H., Truwit C.L., Garwood M., Nyberg S.L., Uğurbil K.
ISSN
1090-7807 (Print)
ISSN-L
1090-7807
Statut éditorial
Publié
Date de publication
1998
Volume
135
Numéro
1
Pages
260-264
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
The measurement of cerebral metabolites using highly homologous localization techniques and similar shimming methods was performed in the human brain at 1.5 and 4 T as well as in the dog and rat brain at 9.4 T. In rat brain, improved resolution was achieved by shimming all first- and second-order shim coils using a fully adiabatic FASTMAP sequence. The spectra showed a clear improvement in spectral resolution for all metabolite resonances with increased field strength. Changes in cerebral glutamine content were clearly observed at 4 T compared to 1.5 T in patients with hepatic encephalopathy. At 9.4 T, glutamine H4 at 2.46 ppm was fully resolved from glutamate H4 at 2.37 ppm, as was the potential resonance from gamma-amino-butyric acid at 2.30 ppm and N-acetyl-aspartyl-glutamate at 2.05 ppm. Singlet linewidths were found to be as low as 6 Hz (0.015 ppm) at 9.4 T, indicating a substantial decrease in ppm linewidth with field strength. Furthermore, the methylene peak of creatine was partially resolved from phosphocreatine, indicating a close to 1:1 relationship in gray matter. We conclude that increasing the magnetic field strength increases spectral resolution also for 1H NMR, which can lead to more than linear sensitivity gains.
Mots-clé
Adult, Amino Acids/analysis, Animals, Brain Chemistry, Dogs, Hepatic Encephalopathy/metabolism, Humans, Image Processing, Computer-Assisted, Inositol/analysis, Lactic Acid/analysis, Magnetic Resonance Spectroscopy, Protons, Rats, Reproducibility of Results, Stereoisomerism
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
20/08/2019 14:02
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