Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage-Protocol of a Swiss Nationwide Observational Study (MoCA-DCI Study).

Détails

ID Serval
serval:BIB_24340B7DFDB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage-Protocol of a Swiss Nationwide Observational Study (MoCA-DCI Study).
Périodique
Neurosurgery
Auteur(s)
Stienen M.N., Fung C., Bijlenga P., Zumofen D.W., Maduri R., Robert T., Seule M.A., Marbacher S., Geisseler O., Brugger P., Gutbrod K., Chicherio C., Monsch A.U., Beaud V., Rossi S., Früh S., Schmid N., Smoll N.R., Keller E., Regli L.
Collaborateur(s)
MoCA-DCI study group
ISSN
1524-4040 (Electronic)
ISSN-L
0148-396X
Statut éditorial
Publié
Date de publication
01/05/2019
Peer-reviewed
Oui
Volume
84
Numéro
5
Pages
1124-1132
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: ppublish
Résumé
The exact relationship between delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and neuropsychological impairment remains unknown, as previous studies lacked a baseline examination after aneurysm occlusion but before the DCI-period. Neuropsychological evaluation of acutely ill patients is often applied in a busy intensive care unit (ICU), where distraction represents a bias to the obtained results.
To evaluate the relationship between DCI and neuropsychological outcome after aSAH by comparing the Montreal Cognitive Assessment (MoCA) results in aSAH patients with and without DCI at 3 mo with a baseline examination before the DCI-period (part 1). To determine the reliability of the MoCA, when applied in an ICU setting (part 2).
Prospective, multicenter, and observational study performed at all Swiss neurovascular centers. For part 1, n = 240 consecutive aSAH patients and for part 2, n = 50 patients with acute brain injury are recruited.
Part 1: Effect size of the relationship between DCI and neuropsychological outcome (MoCA). Part 2: Reliability measures for the MoCA.
The institutional review boards approved this study on July 4, 2017 under case number BASEC 2017-00103. After completion, the results will be offered to an international scientific journal for peer-reviewed publication. This study determines the exact impact of DCI on the neuropsychological outcome after aSAH, unbiased by confounding factors such as early brain injury or patient-specific characteristics. The study provides unique insights in the neuropsychological state of patients in the early period after aSAH.
Mots-clé
Brain Ischemia/complications, Cognitive Dysfunction/epidemiology, Cognitive Dysfunction/etiology, Female, Humans, Male, Mental Status and Dementia Tests, Middle Aged, Prospective Studies, Reproducibility of Results, Research Design, Subarachnoid Hemorrhage/complications, Switzerland, Cognitive disorders, Delayed cerebral ischemia, Montreal Cognitive Assessment, Outcome, Reliability, Stroke, Subarachnoid hemorrhage
Pubmed
Web of science
Création de la notice
27/05/2018 10:51
Dernière modification de la notice
27/04/2020 5:20
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