Cell entry by human pathogenic arenaviruses.

Détails

ID Serval
serval:BIB_23C97FE9C337
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cell entry by human pathogenic arenaviruses.
Périodique
Cellular Microbiology
Auteur(s)
Rojek J.M., Kunz S.
ISSN
1462-5822 (Electronic)
ISSN-L
1462-5814
Statut éditorial
Publié
Date de publication
2008
Volume
10
Numéro
4
Pages
828-835
Langue
anglais
Résumé
The arenaviruses Lassa virus (LASV) in Africa and Machupo (MACV), Guanarito (GTOV) and Junin viruses (JUNV) in South America cause severe haemorrhagic fevers in humans with fatality rates of 15-35%. The present review focuses on the first steps of infection with human pathogenic arenaviruses, the interaction with their cellular receptor molecules and subsequent entry into the host cell. While similarities exist in genomic organization, structure and clinical disease caused by pathogenic Old World and New World arenaviruses these pathogens use different primary receptors. The Old World arenaviruses employ alpha-dystroglycan, a cellular receptor for proteins of the extracellular matrix, and the human pathogenic New World arenaviruses use the cellular cargo receptor transferrin receptor 1. While the New World arenavirus JUNV enters cells via clathrin-dependent endocytosis, evidence occurred for clathrin-independent entry of the prototypic Old World arenavirus lymphocytic choriomeningitis virus. Upon internalization, arenaviruses are delivered to the endosome, where pH-dependent membrane fusion is mediated by the envelope glycoprotein (GP). While arenavirus GPs share characteristics with class I fusion GPs of other enveloped viruses, unusual mechanistic features of GP-mediated membrane fusion have recently been discovered for arenaviruses with important implications for viral entry.
Mots-clé
Animals, Arenavirus/growth & development, Arenavirus/metabolism, Arenaviruses, New World/growth & development, Arenaviruses, New World/metabolism, Arenaviruses, Old World/growth & development, Arenaviruses, Old World/metabolism, Endocytosis/physiology, Humans, Models, Biological, Receptors, Cell Surface/physiology, Virus Attachment
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/04/2013 17:47
Dernière modification de la notice
20/08/2019 14:01
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