Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.

Détails

ID Serval
serval:BIB_23794C1BD804
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.
Périodique
Cell
Auteur⸱e⸱s
Acha-Orbea H., Mitchell D.J., Timmermann L., Wraith D.C., Tausch G.S., Waldor M.K., Zamvil S.S., McDevitt H.O., Steinman L.
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
1988
Volume
54
Numéro
2
Pages
263-273
Langue
anglais
Résumé
Experimental allergic encephalomyelitis (EAE) is an induced autoimmune disease mediated by CD4+ T lymphocytes. Analysis of T cell receptors of myelin basic protein-specific encephalitogenic T cell clones derived from six different PL/J (H-2u) or (PL/J x SJL) F1 (H-2uxs) mice revealed a limited heterogeneity in primary structure. In vivo, the majority of T lymphocytes recognize the N-terminal MBP-nonapeptide in association with I-Au and utilize the V beta 8 gene element. cDNA-sequencing showed that all T cell receptors from a panel of such T cell clones, grown in vitro, share the same V alpha gene segment. Despite heterogeneity in the D-J regions, the clones unexpectedly display a striking similarity in fine specificity. Based on these results, prevention and reversal of autoimmune disease with V beta 8-specific monoclonal antibodies was achieved.
Mots-clé
Amino Acid Sequence, Animals, Antibodies, Monoclonal/therapeutic use, Autoimmune Diseases/immunology, Autoimmune Diseases/therapy, Base Sequence, Clone Cells, Cross Reactions, Encephalomyelitis, Autoimmune, Experimental/immunology, Encephalomyelitis, Autoimmune, Experimental/therapy, Epitopes/analysis, Female, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Random Allocation, Receptors, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell/immunology, Sequence Homology, Nucleic Acid, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 13:01
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