Propylene glycol monomethyl ether occupational exposure. 3. Exposure of human volunteers.

Détails

ID Serval
serval:BIB_23014
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Propylene glycol monomethyl ether occupational exposure. 3. Exposure of human volunteers.
Périodique
International Archives of Occupational and Environmental Health
Auteur(s)
Devanthéry A., Berode M., Droz P.O.
ISSN
0340-0131
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
75
Numéro
4
Pages
203-208
Langue
anglais
Résumé
OBJECTIVE: Propylene glycol monomethyl ether (PGME) is a widely used additive in industrial and consumer products (paints, inks, diluents, cleaning products, cosmetics.). The aim of the present study was to determine uptake and disposition of PGME alpha-isomer in humans. METHOD: Six healthy male volunteers were exposed to PGME-alpha vapour (15, 50 and 95 ppm) with and without respiratory protection for 6 h including a 30-min break. Free PGME and total PGME (free and conjugated) were analysed in urine. The analytical method involved hydrolysis with HCl (only for the analysis of total PGME in urine), a solid phase extraction on LC-18 columns and a gas chromatograph-flame ionisation detector (GC/FID) analysis after derivatisation with trimethylsilylimidazole. RESULTS: End-exposure levels of free PGME in urine were found to reach 1.3 (+/-0.3), 4.4 (+/-1.6) and 7.9 (+/-2.5) mg/l for 15, 50 and 95-ppm exposure, respectively, without respiratory protection. End-exposure levels of total PGME in urine were found to reach 2.5 (+/-0.8), 6.2 (+/-1.6) and 10.3 (+/-2.3) mg/l for 15, 50 and 95-ppm exposure respectively. Levels of free PGME were also monitored in exhaled air (0.4 (+/-0.1), 1.4 (+/-0.4) and 2.9 (+/-0.9) ppm at the end of 15, 50 and 95-ppm exposure, respectively) and in blood (2.0 (+/-0.9), 4.9 (+/-2.3) and 11.8 (+/-2.4) mg/l at the end of 15, 50 and 95-ppm exposure, respectively). PGME is rapidly excreted in urine and in exhaled air; the half-lives were calculated to be approximately 3.5 h in urine and 10 min in exhaled air. PGME was below detection limits in breath (<0.1 ppm), in blood (<1 mg/l) and in urine (<1 mg/l) after dermal-only exposure to vapour. CONCLUSIONS: This study has demonstrated the relatively high pulmonary uptake compared with the dermal uptake. It has also shown the rapid excretion in urine (3.5 h) and in expired air (10 min). With regard to metabolism, this study has established the presence of conjugated PGME in urine.
Mots-clé
Adult, Breath Tests, Chromatography, Gas, Half-Life, Humans, Inhalation Exposure, Male, Occupational Exposure, Propylene Glycols, Respiratory Protective Devices
Pubmed
Web of science
Création de la notice
19/11/2007 12:18
Dernière modification de la notice
20/08/2019 13:00
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