Hepatitis C virus proteins promote mitochondrial bioenergetic dysfunction and nitro-oxidative stress: insights into pathogenesis

Détails

ID Serval
serval:BIB_22EA9AFD3B20
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hepatitis C virus proteins promote mitochondrial bioenergetic dysfunction and nitro-oxidative stress: insights into pathogenesis
Périodique
Drug Discovery Today: Disease Mechanisms
Auteur⸱e⸱s
Capitanio N., Moradpour D., Piccoli C.
ISSN
1740-6765 (Print)
Statut éditorial
Publié
Date de publication
2009
Volume
6
Numéro
1-4
Pages
e3-e10
Langue
anglais
Résumé
HCV-infection induces a state of oxidative stress more pronounced than in many other inflammatory diseases. Here we propose a temporal sequence of events in the HCV-infected cell whereby the primary alteration consists in release of Ca2+ from the ER followed by uptake into mitochondria. This triggers successive mitochondrial dysfunctions leading to generation of ROS and to a progressive metabolic adaptive response. Pathogenetic implications of the model and new opportunities for therapeutic intervention are discussed.
Création de la notice
01/02/2010 10:38
Dernière modification de la notice
20/08/2019 14:00
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