Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome

Détails

ID Serval
serval:BIB_223216933333
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome
Périodique
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Auteur⸱e⸱s
Gerber  S., Bongiovanni  A. M., Ledger  W. J., Witkin  S. S.
ISSN
0301-2115 (Print)
Statut éditorial
Publié
Date de publication
03/2003
Volume
107
Numéro
1
Pages
74-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 26
Résumé
OBJECTIVE: The pathogenesis of vulvar vestibulitis syndrome remains unknown but may be related to a localized chronic inflammation. The relation between this syndrome and a polymorphism at position +3953 in the interleukin-1beta gene was examined. Allele 2 of this gene has been associated with increased pro-inflammatory immunity. STUDY DESIGN: Buccal or vestibular swabs from 59 women with strictly defined vulvar vestibulitis and from 48 healthy women were tested by polymerase chain reaction for the presence of two alleles at the +3953 interleukin-1beta locus. RESULTS: Allele 2 of the interleukin-1beta gene was identified in 27 (46%) women with vulvar vestibulitis as opposed to 12 (25%) control women (P=0.03). The interleukin-1beta 1,1 genotype was present in 36 (75%) controls as opposed to 32 (54%) vulvar vestibulitis syndrome patients (P=0.02). All subjects had been previously tested for induced interleukin-1beta production in response to bacterial lipopolysaccharide. In both patients and controls, possession of allele 2 was associated with a small but non-statistically significant increase in induced interleukin-1beta production. CONCLUSION: Allele 2 in the interleukin-1beta gene is more common in women with vulvar vestibulitis syndrome than in other women. Susceptibility to vulvar vestibulitis syndrome might be influenced by carriage of this polymorphism.
Mots-clé
Alleles Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Interleukin-1/biosynthesis/*genetics Lipopolysaccharides/pharmacology Polymerase Chain Reaction *Polymorphism, Genetic Syndrome Vulvovaginitis/*genetics
Pubmed
Web of science
Création de la notice
25/01/2008 15:45
Dernière modification de la notice
20/08/2019 12:59
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