Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Détails
ID Serval
serval:BIB_2231E85EF2A5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Périodique
Cell
ISSN
0092-8674 (Print)
Statut éditorial
Publié
Date de publication
09/2006
Volume
126
Numéro
6
Pages
1135-45
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 22
Research Support, Non-U.S. Gov't --- Old month value: Sep 22
Résumé
Many pathogenic organisms produce pore-forming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promotes the formation of a multiprotein oligomeric innate immune complex, called the inflammasome, and the activation of caspase-1. Further, we find that when rendered proteolytic in this context caspase-1 induces the activation of the central regulators of membrane biogenesis, the Sterol Regulatory Element Binding Proteins (SREBPs), which in turn promote cell survival upon toxin challenge possibly by facilitating membrane repair. This study highlights that, in addition to its well-established role in triggering inflammation via the processing of the precursor forms of interleukins, caspase-1 has a broader role, in particular linking the intracellular ion composition to lipid metabolic pathways, membrane biogenesis, and survival.
Mots-clé
Aeromonas/metabolism
Animals
Bacterial Infections/metabolism/physiopathology
Bacterial Toxins/*metabolism/pharmacology
CHO Cells
Caspase 1/*metabolism
Cell Membrane/drug effects/*metabolism
Cell Membrane Permeability/drug effects/physiology
Cell Survival/physiology
Cricetinae
Hela Cells
Humans
Immunity, Natural/*physiology
Membrane Lipids/*metabolism
Pore Forming Cytotoxic Proteins
Potassium/metabolism
Sterol Regulatory Element Binding Protein 2/metabolism
Sterol Regulatory Element Binding Proteins/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 13:59