Hemoglobin substitute and cardiopulmonary bypass

Détails

ID Serval
serval:BIB_220B3DF06BA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hemoglobin substitute and cardiopulmonary bypass
Périodique
ASAIO Journal
Auteur⸱e⸱s
Mueller  X. M., Tevaearai  H. T., Jegger  D., Mallabiabarrena  I., Gardaz  J. P., von Segesser  L. K.
ISSN
1058-2916 (Print)
Statut éditorial
Publié
Date de publication
08/2000
Volume
46
Numéro
4
Pages
403-8
Notes
Journal Article --- Old month value: Jul-Aug
Résumé
The effects of diaspirin crosslinked hemoglobin (DCLHb, Baxter Health Care Corp., Round Lake, IL) on oxygen exchange in the setting of cardiopulmonary bypass (CPB) are unknown. Six calves (71.2 +/- 1.3 kg) were connected to CPB by jugular venous and carotid arterial cannulation for 5 hours. Each 1 hour period included 45 min of partial CPB (mean flow rate of 50 ml/kg per min) followed by 15 min without CPB, at the end of which 500 ml of blood were substituted for with either 500 ml of hydroxyethyl starch (Haes; n = 3) or 500 ml of DCLHb (n = 3). A total of 2 liters of blood was, thus, exchanged (28 ml/kg of blood substitute). Values are expressed as mean +/- 1 SD. Analysis of variance for repeated measurements was used. The cardiac output (CO) values at 1 h, 3 h, and 5 h were in the Haes group: 5.7 +/- 2, 6.7 +/- 2.5, and 7.7 +/- 2.5L/min, and in the DCLHb group: 5.7 +/- 0.6, 4 +/- 1, and 4.7 +/- 1.2 L/min, respectively. The arteriovenous oxygen content difference (Ca-Cvo2) values at 1 h, 3 h, and 5 h were in the Haes group: 4.6 +/- 1, 3.3 +/- 1.5, and 3.5 +/- 1.5 ml/dl, and in the DCLHb group: 4.9 +/- 0.6, 7.4 +/- 0.7, and 6.6 +/- 0.6 ml/dl, respectively. The oxygen consumption (Vo2) values at 1 h, 3 h, and 5 h were in the Haes group: 244 +/- 29, 198 +/- 58, and 249 +/- 42 ml/min, and in the DCLHb group: 273 +/- 28, 296 +/- 75, and 306 +/- 65 ml/min, respectively. CO and Ca-Cvo2 showed a significant difference (p < 0.01), whereas Vo2 did not (p = 0.52). In the DCLHb group of this CPB animal model, the cardiac output is lower and the arteriovenous oxygen content difference higher than in the Haes group, allowing for preserved oxygen consumption.
Mots-clé
Animals Aspirin/*analogs & derivatives/pharmacology Blood Substitutes/*pharmacology *Cardiopulmonary Bypass Cattle Hemodynamic Processes/drug effects Hemoglobins/*pharmacology Oxygen/blood
Pubmed
Web of science
Création de la notice
28/01/2008 10:48
Dernière modification de la notice
20/08/2019 12:58
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