Simultaneous in vivo spectral editing and water suppression.

Détails

ID Serval
serval:BIB_22005548F525
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous in vivo spectral editing and water suppression.
Périodique
NMR in Biomedicine
Auteur(s)
Mescher M., Merkle H., Kirsch J., Garwood M., Gruetter R.
ISSN
0952-3480 (Print)
ISSN-L
0952-3480
Statut éditorial
Publié
Date de publication
1998
Volume
11
Numéro
6
Pages
266-272
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Water suppression is typically performed in vivo by exciting the longitudinal magnetization in combination with dephasing, or by using frequency-selective coherence generation. MEGA, a frequency-selective refocusing technique, can be placed into any pulse sequence element designed to generate a Hahn spin-echo or stimulated echo, to dephase transverse water coherences with minimal spectral distortions. Water suppression performance was verified in vivo using stimulated echo acquisition mode (STEAM) localization, which provided water suppression comparable with that achieved with four selective pulses in 3,1-DRYSTEAM. The advantage of the proposed method was exploited for editing J-coupled resonances. Using a double-banded pulse that selectively inverts a J-coupling partner and simultaneously suppresses water, efficient metabolite editing was achieved in the point resolved spectroscopy (PRESS) and STEAM sequences in which MEGA was incorporated. To illustrate the efficiency of the method, the detection of gamma-aminobutyric acid (GABA) was demonstrated, with minimal contributions from macromolecules and overlying singlet peaks at 4 T. The estimated occipital GABA concentration was consistent with previous reports, suggesting that editing for GABA is efficient when based on MEGA at high field strengths.
Mots-clé
Brain Chemistry, Creatine/analysis, Humans, Magnetic Resonance Spectroscopy/methods, Magnetics, Water/chemistry, gamma-Aminobutyric Acid/analysis
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
20/08/2019 13:58
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