Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas.

Détails

ID Serval
serval:BIB_21F35B6B6D35
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas.
Périodique
American journal of ophthalmology
Auteur⸱e⸱s
Kymionis G.D., Portaliou D.M., Diakonis V.F., Kounis G.A., Panagopoulou S.I., Grentzelos M.A.
ISSN
1879-1891 (Electronic)
ISSN-L
0002-9394
Statut éditorial
Publié
Date de publication
01/2012
Peer-reviewed
Oui
Volume
153
Numéro
1
Pages
24-28
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To report the outcomes after corneal collagen cross-linking (CXL) treatment with riboflavin and ultraviolet-A (UVA) irradiation in patients with thin corneas (minimum corneal thickness less than 400 μm after epithelial removal and before riboflavin instillation).
Prospective case series.
Twelve patients (14 eyes, with minimum corneal thickness less than 400 μm after epithelial removal) were included in the study. All patients underwent riboflavin-UVA-induced CXL using the standard CXL (Dresden) protocol. Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) (decimal scale), manifest refraction (diopters, D), and topography were evaluated at baseline and at 1, 3, 6, and 12 months follow-up. Images of the endothelium were acquired with a modified confocal scanning laser ophthalmoscope.
No intraoperative or postoperative complications were observed in this patient series. Mean minimum preoperative corneal thickness at the apex of the cone after epithelial removal and before riboflavin instillation was 373.92 ± 22.92 μm (range 340-399 μm). UDVA and CDVA improved from 0.25 ± 0.15 and 0.40 ± 0.20 to 0.27 ± 0.17 and 0.49 ± 0.20 respectively at the last follow-up examination. There was a reduction of the mean keratometry readings from 51.99 ± 5.57 D to 49.33 ± 4.82 D at the last follow-up. A significant decrease of endothelial cell density was observed (preoperative: 2733 ± 180 cells/mm(2) [range 2467-3016], last follow-up visit: 2441 ± 400 cells/mm(2) [range 1448-2920], P < .01).
CXL in thin corneas with minimum corneal thickness less than 400 μm after epithelial removal seems to result in a significant endothelial cell density decrease postoperatively. This finding was not related to other intraoperative or postoperative complications.
Mots-clé
Adult, Cell Count, Collagen/metabolism, Corneal Endothelial Cell Loss/diagnosis, Corneal Endothelial Cell Loss/etiology, Corneal Stroma/metabolism, Corneal Stroma/pathology, Corneal Topography, Cross-Linking Reagents/therapeutic use, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/pathology, Male, Microscopy, Confocal, Ophthalmoscopy, Photosensitizing Agents/therapeutic use, Prospective Studies, Riboflavin/therapeutic use, Treatment Outcome, Ultraviolet Rays, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Création de la notice
01/10/2019 15:14
Dernière modification de la notice
06/10/2019 6:26
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