Data triangulation in the context of opioids monitoring via wastewater analyses.

Détails

ID Serval
serval:BIB_21E7DA10B434
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Data triangulation in the context of opioids monitoring via wastewater analyses.
Périodique
Drug and Alcohol Dependence
Auteur(s)
Been F., Benaglia L., Lucia S., Gervasoni J.P., Esseiva P., Delémont O.
ISSN
1879-0046 (Electronic)
ISSN-L
0376-8716
Statut éditorial
Publié
Date de publication
06/2015
Peer-reviewed
Oui
Volume
151
Numéro
151
Pages
203-210
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BACKGROUND: The need to contextualise wastewater-based figures about illicit drug consumption by comparing them with other indicators has been stressed by numerous studies. The objective of the present study was to further investigate the possibility of combining wastewater data to conventional statistics to assess the reliability of the former method and obtain a more balanced picture of illicit drug consumption in the investigated area.
METHODS: Wastewater samples were collected between October 2013 and July 2014 in the metropolitan area of Lausanne (226,000 inhabitants), Switzerland. Methadone, its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), the exclusive metabolite of heroin, 6-monoacetylmorphine (6-MAM), and morphine loads were used to estimate the amounts of methadone and heroin consumed.
RESULTS: Methadone consumption estimated from EDDP was in agreement with the expectations. Heroin estimates based on 6-MAM loads were inconsistent. Estimates obtained from morphine loads, combined to prescription/sales data, were in agreement with figures derived from syringe distribution data and general population surveys.
CONCLUSIONS: The results obtained for methadone allowed assessing the reliability of the selected sampling strategy, supporting its ability to capture the consumption of a small cohort (i.e., 743 patients). Using morphine as marker, in combination with prescription/sales data, estimates in accordance with other indicators about heroin use were obtained. Combining different sources of data allowed strengthening the results and suggested that the different indicators (i.e., administration route, average dosage and number of consumers) contribute to depict a realistic representation of the phenomenon in the investigated area. Heroin consumption was estimated to approximately 13gday(-1) (118gday(-1) at street level).
Pubmed
Web of science
Création de la notice
23/04/2015 13:44
Dernière modification de la notice
20/08/2019 13:58
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