MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T.

Détails

ID Serval
serval:BIB_21B18A2361D1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Mekle R., Mlynárik V., Gambarota G., Hergt M., Krueger G., Gruetter R.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2009
Volume
61
Numéro
6
Pages
1279-1285
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Recently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPECIAL was adapted and optimized for use on a clinical platform at 3T and 7T by combining interleaved water suppression (WS) and outer volume saturation (OVS), optimized sequence timing, and improved shimming using FASTMAP. High-quality single voxel spectra of human brain were acquired at TEs below or equal to 6 ms on a clinical 3T and 7T system for six volunteers. Narrow linewidths (6.6 +/- 0.6 Hz at 3T and 12.1 +/- 1.0 Hz at 7T for water) and the high signal-to-noise ratio (SNR) of the artifact-free spectra enabled the quantification of a neurochemical profile consisting of 18 metabolites with Cramér-Rao lower bounds (CRLBs) below 20% at both field strengths. The enhanced sensitivity and increased spectral resolution at 7T compared to 3T allowed a two-fold reduction in scan time, an increased precision of quantification for 12 metabolites, and the additional quantification of lactate with CRLB below 20%. Improved sensitivity at 7T was also demonstrated by a 1.7-fold increase in average SNR (= peak height/root mean square [RMS]-of-noise) per unit-time.
Mots-clé
Algorithms, Brain Chemistry, Humans, Magnetic Resonance Spectroscopy/methods, Neurotransmitter Agents/analysis, Protons/diagnostic use, Reproducibility of Results, Sensitivity and Specificity
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/08/2010 15:28
Dernière modification de la notice
20/08/2019 12:58
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