A Simplified Model for Intravoxel Incoherent Motion Perfusion Imaging of the Brain.

Détails

ID Serval
serval:BIB_2194EE980850
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Simplified Model for Intravoxel Incoherent Motion Perfusion Imaging of the Brain.
Périodique
AJNR. American journal of neuroradiology
Auteur(s)
Conklin J., Heyn C., Roux M., Cerny M., Wintermark M., Federau C.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
37
Numéro
12
Pages
2251-2257
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Despite a recent resurgence, intravoxel incoherent motion MRI faces practical challenges, including limited SNR and demanding acquisition and postprocessing requirements. A simplified approach using linear fitting of a subset of higher b-values has seen success in other organ systems. We sought to validate this method for evaluation of brain pathology by comparing perfusion measurements using simplified linear fitting to conventional biexponential fitting.
Forty-nine patients with gliomas and 17 with acute strokes underwent 3T MRI, including DWI with 16 b-values (range, 0-900 s/mm2). Conventional intravoxel incoherent motion was performed using nonlinear fitting of the standard biexponential equation. Simplified intravoxel incoherent motion was performed using linear fitting of the log-normalized signal curves for subsets of b-values >200 s/mm2. Comparisons between ROIs (tumors, strokes, contralateral brain) and between models (biexponential and simplified linear) were performed by using 2-way ANOVA. The root mean square error and coefficient of determination (R2) were computed for the simplified model, with biexponential fitting as the reference standard.
Perfusion maps using simplified linear fitting were qualitatively similar to conventional biexponential fitting. The perfusion fraction was elevated in high-grade (n = 33) compared to low-grade (n = 16) gliomas and was reduced in strokes compared to the contralateral brain (P < .001 for both main effects). Decreasing the number of b-values used for linear fitting resulted in reduced accuracy (higher root mean square error and lower R2) compared with full biexponential fitting.
Intravoxel incoherent motion perfusion imaging of common brain pathology can be performed by using simplified linear fitting, with preservation of clinically relevant perfusion information.

Mots-clé
Brain/diagnostic imaging, Brain/pathology, Brain Neoplasms/blood supply, Brain Neoplasms/diagnostic imaging, Brain Neoplasms/pathology, Diffusion Magnetic Resonance Imaging/methods, Female, Glioma/blood supply, Glioma/diagnostic imaging, Glioma/pathology, Humans, Image Interpretation, Computer-Assisted/methods, Magnetic Resonance Imaging, Male, Middle Aged, Models, Theoretical, Motion, Perfusion Imaging/methods, Reproducibility of Results, Stroke/diagnostic imaging, Stroke/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/09/2016 19:30
Dernière modification de la notice
20/08/2019 12:58
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