Radial asymmetry in the topography of retinoblastoma. Clues to the cell of origin

Détails

ID Serval
serval:BIB_2193253FEF42
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Radial asymmetry in the topography of retinoblastoma. Clues to the cell of origin
Périodique
Ophthalmic Genetics
Auteur(s)
Munier  F. L., Balmer  A., van Melle  G., Gailloud  C.
ISSN
1381-6810 (Print)
Statut éditorial
Publié
Date de publication
12/1994
Volume
15
Numéro
3-4
Pages
101-6
Notes
Journal Article --- Old month value: Sep-Dec
Résumé
Retinoblastoma is a malignancy of the human developing retina. In situ as well as in vitro studies have attributed tumoral histogenesis either to a primitive retinoblast with neuronal and glial differentiation potentials, or to a photosensory progenitor cell. Here it is shown in vivo that the retinal topography of 457 retinoblastoma and retinoma foci is radially asymmetrical. Tumor density appears to mimic the horizontal visual streak characteristic of red/green cone cell distribution. Such a non-random distribution seems to invalidate the hypothesis of a primitive multipotential neuroblast as the unique source of retinoblastoma and may support the view that retinoblastoma evolves along the cone cell lineage.
Mots-clé
Cones (Retina)/pathology Eye Neoplasms/genetics/*pathology Female Humans Male Ophthalmoscopy Retina/pathology Retinoblastoma/genetics/*pathology
Pubmed
Web of science
Création de la notice
28/01/2008 13:54
Dernière modification de la notice
20/08/2019 13:58
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