QuantiFERON®-CMV assay for the assessment of cytomegalovirus cell-mediated immunity.

Détails

ID Serval
serval:BIB_217927B78EB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
QuantiFERON®-CMV assay for the assessment of cytomegalovirus cell-mediated immunity.
Périodique
Expert Review of Molecular Diagnostics
Auteur(s)
Giulieri S., Manuel O.
ISSN
1744-8352[electronic], 1473-7159[linking]
Statut éditorial
Publié
Date de publication
2011
Volume
11
Numéro
1
Pages
17-25
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Cytomegalovirus (CMV) infection has historically been a major complication among immunocompromised patients, such as solid-organ and stem-cell transplant recipients and patients with advanced HIV infection. While the introduction of antiretroviral therapy has almost eradicated CMV infection in HIV-infected patients, CMV disease remains a significant problem in transplant recipients once antiviral prophylaxis is discontinued. QuantiFERON(®)-CMV allows the assessment of cellular immunity against CMV by detecting the production of IFN-γ following in vitro stimulation with CMV antigens. Preliminary studies have shown a correlation between a lack of detectable cell-mediated immunity measured by the QuantiFERON-CMV assay and a higher incidence of CMV infection and disease in immunocompromised patients. Measurement of cell-mediated immunity against CMV appears to be a promising strategy to identify patients at highest risk for the development of CMV disease and, therefore, to individualize preventive strategies for CMV in transplant recipients.
Pubmed
Web of science
Création de la notice
03/02/2011 15:02
Dernière modification de la notice
20/08/2019 12:58
Données d'usage