Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Détails

ID Serval
serval:BIB_21687B75D2D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Périodique
Nature
Auteur(s)
Malanchi I., Peinado H., Kassen D., Hussenet T., Metzger D., Chambon P., Huber M., Hohl D., Cano A., Birchmeier W., Huelsken J.
ISSN
1476-4687[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
452
Numéro
7187
Pages
650-653
Langue
anglais
Résumé
Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular origin of these CSCs and regulatory pathways essential for sustaining stemness have not been identified. In murine skin, follicular morphogenesis is driven by bulge stem cells that specifically express CD34. Here we identify a population of cells in early epidermal tumours characterized by phenotypic and functional similarities to normal bulge skin stem cells. This population contains CSCs, which are the only cells with tumour initiation properties. Transplants derived from these CSCs preserve the hierarchical organization of the primary tumour. We describe beta-catenin signalling as being essential in sustaining the CSC phenotype. Ablation of the beta-catenin gene results in the loss of CSCs and complete tumour regression. In addition, we provide evidence for the involvement of increased beta-catenin signalling in malignant human squamous cell carcinomas. Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas.
Mots-clé
Animals, Antigens, CD34/metabolism, Cell Line, Tumor, Cell Transformation, Neoplastic, Cells, Cultured, Epidermis/pathology, Humans, Mice, Mice, Nude, Neoplasm Transplantation, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Signal Transduction, Skin Neoplasms/pathology, beta Catenin/metabolism
Pubmed
Web of science
Création de la notice
02/10/2009 17:27
Dernière modification de la notice
20/08/2019 12:58
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