Structural insights into the SNARE mechanism.

Détails

ID Serval
serval:BIB_215B6D007219
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Structural insights into the SNARE mechanism.
Périodique
Biochimica et Biophysica Acta-Molecular Cell Research
Auteur⸱e⸱s
Fasshauer D.
ISSN
0167-4889
ISSN-L
1879-2596
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
1641
Numéro
2-3
Pages
87-97
Langue
anglais
Résumé
Eukaryotic cells distribute materials among intracellular organelles and secrete into the extracellular space through cargo-loaded vesicles. A concluding step during vesicular transport is the fusion of a transport vesicle with a target membrane. SNARE proteins are essential for all vesicular fusion steps, thus they possibly comprise a conserved membrane fusion machinery. According to the "zipper" model, they assemble into stable membrane-bridging complexes that gradually bring membranes in juxtaposition. Hence, complex formation may provide the necessary energy for overcoming the repulsive forces between two membranes. During the last years, detailed structural and functional studies have extended the evidence that SNAREs are mostly in accord with the zipper model. Nevertheless, it remains unclear whether SNARE assembly between membranes directly leads to the merger of lipid bilayers.
Mots-clé
Animals, Cell Membrane/physiology, Humans, Membrane Proteins/biosynthesis, Membrane Proteins/chemistry, Models, Molecular, SNARE Proteins, Signal Transduction, Vesicular Transport Proteins
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/09/2011 9:59
Dernière modification de la notice
20/08/2019 12:57
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