Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman.

Détails

ID Serval
serval:BIB_2154763AADCF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Human papilloma virus-associated squamous cell carcinoma of the larynx in an 18-year-old woman.
Périodique
Head & neck
Auteur(s)
Hotz M.A., Christen B., Sahli R., Arnold A.M.
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
41
Numéro
4
Pages
E59-E61
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: ppublish
Résumé
Human papilloma virus (HPV)-associated malignancies are considered to be sexually transmitted diseases.
We report a HPV-positive larynx cancer in an 18-year-old female clarinet player, despite vaccination with the quadrivalent HPV-6-11-16-18-vaccine Gardasil (Merck Sharp & Dohme Corp., West Point, Pennsylvania). The patient showed no evidence of genito-oral infection but showed some evidence for oral-oral HPV transmission through the sharing of saliva-infested clarinet mouthpieces. A right vocal cord lesion of benign appearance was removed via free margin resection.
Histopathology revealed a microinvasive squamous cell carcinoma inside a zone of high-grade dysplasia that was positive for HPV-45. No tumor recurrence was observed during a 4-year follow-up evaluation.
Benign lesion appearance and quadrivalent HPV vaccine status do not exclude HPV-associated malignancies. In our patient, the Gardasil vaccine did not provide crossover protection against HPV 45 infection. HPV-associated disease may not necessarily be transmitted via sexual practice patterns alone.
Mots-clé
human papilloma virus, larynx, squamous cell carcinoma, transmission, vaccination
Pubmed
Web of science
Création de la notice
23/01/2019 11:18
Dernière modification de la notice
20/08/2019 12:57
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