Postoperative neuropsychological dysfunction and cerebral oxygenation during cardiac surgery.

Détails

ID Serval
serval:BIB_213777192699
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Postoperative neuropsychological dysfunction and cerebral oxygenation during cardiac surgery.
Périodique
Thoracic and Cardiovascular Surgeon
Auteur⸱e⸱s
Nollert G., Möhnle P., Tassani-Prell P., Uttner I., Borasio G.D., Schmoeckel M., Reichart B.
ISSN
0171-6425 (Print)
ISSN-L
0171-6425
Statut éditorial
Publié
Date de publication
1995
Volume
43
Numéro
5
Pages
260-264
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
In 41 patients undergoing cardiac operations with extracorporeal circulation, oxidized cytochrome a,a3(CtO2), deoxygenated hemoglobin (Hb), and oxygenated hemoglobin (HbO2) were measured in brain tissue by near-infrared spectrophotometry (NIRS) intraoperatively. Monitoring also included electroencephalography (EEG) and jugular-bulb venous saturation (SBJO2). All operations were performed using membrane oxygenators, moderate hypothermia (26-28 degrees C) and pH alpha-stat management. During cardiopulmonary bypass (CPB) CtO2 and HbO2) were reduced, reaching minimal values when rewarming was instituted. At the end of the operation CtO2 and HbO2 had regained initial levels. During CPB, arterial PCO2, pH, and temperature were closely related to CtO2 (r = 1000, r = -0.964 and 0.929 respectively; p < 0.001, p < 0.001, and p < 0.003 respectively). Neuropsychological testing by the Mini-Mental-State Test indicated reversible postoperative neuropsychological deficits in four patients. There patients had a lower CtO2 minimum compared to those without these deficits (-4.5 mumol/L v. -0.7 mumol/L; p = 0.036). These findings support the hypothesis that neuropsychological deficits in patients after cardiac surgery can be caused by intraoperative cerebral hypoxia.
Mots-clé
Adult, Aged, Blood Gas Analysis, Brain/metabolism, Cardiac Surgical Procedures/adverse effects, Delirium, Dementia, Amnestic, Cognitive Disorders/diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders/etiology, Electron Transport Complex IV/metabolism, Female, Hemoglobins/metabolism, Humans, Hypoxia, Brain/diagnosis, Hypoxia, Brain/etiology, Male, Mental Status Schedule, Middle Aged, Monitoring, Intraoperative, Oxyhemoglobins/metabolism, Spectrophotometry, Infrared
Pubmed
Web of science
Création de la notice
13/01/2014 16:47
Dernière modification de la notice
20/08/2019 12:57
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