Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children.
Détails
ID Serval
serval:BIB_20F5A19D7F58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children.
Périodique
Pediatric critical care medicine
Collaborateur⸱rice⸱s
PlasmaTV Investigators
Contributeur⸱rice⸱s
Camazine M.N., Karam O., Colvin R., Leteurtre S., Demaret P., Tucci M., Muszynski J.A., Stanworth S., Spinella P.C., Butt W., Delzoppo C., Bain K., Erickson S., Smalley N., Dorofaeff T., Long D., Smalley N., Wiseman G., Clément de Cléty S., Berghe C., de Jaeger A., Demaret P., Trippaerts M., Willems A., De Dooy J., Gilfoyle E., Wohlgemuth L., Dumitrascu M., Withington D., Hickey J., Choong K., Sanders L., Morrison G., Tijssen J., Wensley D., Krahn G., Dugas M.A., Gosselin L., Santschi M., Von Dessauer B., Ordenes N., Afshari A., Hoegh Andersen L., Nilsson J.C., Johansen M., Baek Jensen A.M., Campos Mino S., Grunauer M.F., Joram N., Roullet-Renoleau N., Javouhey E., Cour-Andlauer F., Portefaix A., Brissaud O., Guichoux J., Payen V., Léger P.L., Afanetti M., Mortamet G., Maria M., Breining A., Tissieres P., Dorkenoo A., Deho A., Steinherr H., Nikolaou F., Camporesi A., Mario F., Kawasaki T., Miura S., Beca J., Rea M., Sherring C., Bushell T., Bentsen G., Dinis A., Pereira G., Vieira M., Moniz M., Alshehri S., Alasnag M., Rajab A., Pisarcikova M., Jordan I., Balcells J., Perez-Ferrer A., Sánchez J.V., Moyano M.V., Morales Martinez A., Lopez-Herce J., Solana M.J., Flores González J.C., Alonso M.T., Faza M.N., Perez M.H., Amiet V., Doell C., Bordessoule A., Cochius-den Otter S., Kapitein B., Kneyber M., Brierley J., Rea V., McKeever S., Kelleher A., Scholefield B., Top A., Kelly N., Virdee S., Davis P., George S., Hawkins K.C., McCall K., Brown V., Sykes K., Levin R., MacLeod I., Horan M., Jirasek P., Inwald D., Abdulla A., Raghunanan S., Taylor B., Shefler A., Sparkes H., Hanson S., Woods K., Triscari D., Murkowski K., Ozment C., Steiner M., Nerheim D., Galster A., Higgerson R., Christie L., Spinella P., Martin D., Rourke L., Muszynski J., Steele L., Ajizian S., McCrory M.C., O'Brien K., Babbitt C., Felkel E., Levine G., Truemper E.J., Zink M., Nellis M., Thomas N.J., Spear D., Markovitz B., Terry J., Morzov R., Montgomery V., Michael A., Thomas M., Singleton M., Jarvis D., Nett S., Willson D., Hoot M., Bembea M., Yiu A., McKinley D., Scarlett E., Sankey J., Parikh M., Faustino EVS, Michelson K., Rilinger J., Campbell L., Gertz S., Cholette J.M., Jeyapalan A., Parker M., Bateman S., Johnson A.
ISSN
1529-7535 (Print)
ISSN-L
1529-7535
Statut éditorial
Publié
Date de publication
05/2017
Peer-reviewed
Oui
Volume
18
Numéro
5
Pages
e215-e223
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
To determine if the use of fresh frozen plasma/frozen plasma 24 hours compared to solvent detergent plasma is associated with international normalized ratio reduction or ICU mortality in critically ill children.
This is an a priori secondary analysis of a prospective, observational study. Study groups were defined as those transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma. Outcomes were international normalized ratio reduction and ICU mortality. Multivariable logistic regression was used to determine independent associations.
One hundred one PICUs in 21 countries.
All critically ill children admitted to a participating unit were included if they received at least one plasma unit during six predefined 1-week (Monday to Friday) periods. All children were exclusively transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma.
None.
There were 443 patients enrolled in the study. Twenty-four patients (5%) were excluded because no plasma type was recorded; the remaining 419 patients were analyzed. Fresh frozen plasma/frozen plasma 24 hours group included 357 patients, and the solvent detergent plasma group included 62 patients. The median (interquartile range) age and weight were 1 year (0.2-6.4) and 9.4 kg (4.0-21.1), respectively. There was no difference in reason for admission, severity of illness score, pretransfusion international normalized ratio, or lactate values; however, there was a difference in primary indication for plasma transfusion (p < 0.001). There was no difference in median (interquartile range) international normalized ratio reduction, between fresh frozen plasma/frozen plasma 24 hours and solvent detergent plasma study groups, -0.2 (-0.4 to 0) and -0.2 (-0.3 to 0), respectively (p = 0.80). ICU mortality was lower in the solvent detergent plasma versus fresh frozen plasma/frozen plasma 24 hours groups, 14.5% versus 29.1%%, respectively (p = 0.02). Upon adjusted analysis, solvent detergent plasma transfusion was independently associated with reduced ICU mortality (odds ratio, 0.40; 95% CI, 0.16-0.99; p = 0.05).
Solvent detergent plasma use in critically ill children may be associated with improved survival. This hypothesis-generating data support a randomized controlled trial comparing solvent detergent plasma to fresh frozen plasma/frozen plasma 24 hours.
This is an a priori secondary analysis of a prospective, observational study. Study groups were defined as those transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma. Outcomes were international normalized ratio reduction and ICU mortality. Multivariable logistic regression was used to determine independent associations.
One hundred one PICUs in 21 countries.
All critically ill children admitted to a participating unit were included if they received at least one plasma unit during six predefined 1-week (Monday to Friday) periods. All children were exclusively transfused with either fresh frozen plasma/frozen plasma 24 hours or solvent detergent plasma.
None.
There were 443 patients enrolled in the study. Twenty-four patients (5%) were excluded because no plasma type was recorded; the remaining 419 patients were analyzed. Fresh frozen plasma/frozen plasma 24 hours group included 357 patients, and the solvent detergent plasma group included 62 patients. The median (interquartile range) age and weight were 1 year (0.2-6.4) and 9.4 kg (4.0-21.1), respectively. There was no difference in reason for admission, severity of illness score, pretransfusion international normalized ratio, or lactate values; however, there was a difference in primary indication for plasma transfusion (p < 0.001). There was no difference in median (interquartile range) international normalized ratio reduction, between fresh frozen plasma/frozen plasma 24 hours and solvent detergent plasma study groups, -0.2 (-0.4 to 0) and -0.2 (-0.3 to 0), respectively (p = 0.80). ICU mortality was lower in the solvent detergent plasma versus fresh frozen plasma/frozen plasma 24 hours groups, 14.5% versus 29.1%%, respectively (p = 0.02). Upon adjusted analysis, solvent detergent plasma transfusion was independently associated with reduced ICU mortality (odds ratio, 0.40; 95% CI, 0.16-0.99; p = 0.05).
Solvent detergent plasma use in critically ill children may be associated with improved survival. This hypothesis-generating data support a randomized controlled trial comparing solvent detergent plasma to fresh frozen plasma/frozen plasma 24 hours.
Mots-clé
Blood Component Transfusion/methods, Child, Child, Preschool, Critical Illness/mortality, Critical Illness/therapy, Detergents, Female, Humans, Infant, Intensive Care Units, Pediatric, International Normalized Ratio, Logistic Models, Male, Plasma, Prospective Studies, Solvents, Treatment Outcome
Pubmed
Web of science
Création de la notice
01/05/2018 13:15
Dernière modification de la notice
20/08/2019 12:57
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