A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynx

Détails

ID Serval
serval:BIB_20D3450030B2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A prospective study of salivary gland function in patients undergoing radiotherapy for squamous cell carcinoma of the oropharynx
Périodique
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics
Auteur⸱e⸱s
Moller  P., Perrier  M., Ozsahin  M., Monnier  P.
ISSN
1079-2104
Statut éditorial
Publié
Date de publication
02/2004
Peer-reviewed
Oui
Volume
97
Numéro
2
Pages
173-89
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
OBJECTIVE: We sought to investigate the impact of head and neck cancer treatment on salivary function. STUDY DESIGN: The study was conducted on 54 patients with advanced squamous cell carcinoma with confirmed (n = 50) or suspected (n = 4) primary oropharyngeal localization who were treated with radiation alone or in combination with surgery or chemotherapy, or both. The following groups were considered in the evaluation: 1, the entire pool of patients; 2, those undergoing surgery and those not undergoing surgery before radiation; 3, those undergoing resection and those not undergoing resection of the submandibular gland. The flow rates, pH, and buffering capacity were determined before, during, and up to 12 months after the completion of radiation. RESULTS: Head and neck surgery, particularly when submandibular gland resection was performed, had a negative impact on salivary flow rates but did not influence pH or buffering capacity. Nonetheless, the effect of surgery on salivary flow rates decreased progressively and disappeared at 3 to 6 months after radiotherapy. More than two thirds of the salivary output was lost during radiation treatment. All patients were experiencing salivary dysfunction at 1 year after completion of radiotherapy, with average decreases of 93% (P < .0001) and 95% (P < .0001) for whole resting salivary flow and whole stimulated salivary flow, respectively, compared with the preradiotherapy values. The buffering capacity decreased to 67% of its preradiotherapy value, and whole stimulated saliva became acidic. CONCLUSIONS: The result of this study confirms that cancer treatment involving full-dose radiotherapy (RTH) to all major salivary glands for locally advanced squamous cell carcinoma of the oropharynx induces severe hyposalivation with alteration of salivary pH and buffering capacity. Head and neck surgery has a negative impact on salivary flow rates, especially when the submandibular gland is removed. However, surgery before irradiation is not a factor aggravating hyposalivation when postoperative radiotherapy includes all the major salivary glands.
Mots-clé
Adult Aged Analysis of Variance Buffers Carcinoma, Squamous Cell/*radiotherapy/surgery Chemotherapy, Adjuvant Female Follow-Up Studies Humans Hydrogen-Ion Concentration Male Middle Aged Oropharyngeal Neoplasms/*radiotherapy/surgery Prospective Studies Saliva/radiation effects Salivary Glands/*radiation effects/secretion Secretory Rate/radiation effects Submandibular Gland/surgery Xerostomia/etiology
Pubmed
Web of science
Création de la notice
24/01/2008 17:16
Dernière modification de la notice
20/08/2019 12:57
Données d'usage