Less developed corpus callosum in dyslexic subjects--a structural MRI study.

Détails

ID Serval
serval:BIB_20A08B504BC7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Less developed corpus callosum in dyslexic subjects--a structural MRI study.
Périodique
Neuropsychologia
Auteur⸱e⸱s
von Plessen K., Lundervold A., Duta N., Heiervang E., Klauschen F., Smievoll A.I., Ersland L., Hugdahl K.
ISSN
0028-3932 (Print)
ISSN-L
0028-3932
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
40
Numéro
7
Pages
1035-1044
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Based on previous studies and due to the characteristics of dyslexia as an auditory phonological decoding disorder, we predicted that the shape of the posterior corpus callosum (CC) would differ between dyslexic and control subjects.
Twenty right-handed boys with developmental dyslexia were selected from a carefully screened general population sample (mean age 11 years) and compared to a matched control group. The CC contour was manually traced on the aligned midsagittal MR slice and total callosal area and its subregions were compared between the groups. A statistical shape analysis and subsequent CC classification was performed using a recently developed shape model method.
The shape analysis revealed shorter CC shape in the dyslexic group, localised in the posterior midbody/isthmus region. This region contains interhemispheric fibers from primary and secondary auditory cortices. A shape length difference larger than a fixed threshold in the posterior midbody region could correctly discriminate between control and dyslexic subject in 78% of the cases, where a dyslexic CC was shorter in this region than a control CC. However, there were no significant group differences with respect to overall CC area or subregions.
A clear shape difference in the posterior midbody of the CC was found between dyslexic and control subjects. This fits with recent other studies that have reported a strong growth factor in this CC region during the late childhood years, coinciding with literacy acquisition. Our results show that the dyslexic group has not undergone the same growth pattern as the normal reading group.
Mots-clé
Agenesis of Corpus Callosum, Child, Corpus Callosum/growth & development, Corpus Callosum/pathology, Dyslexia/physiopathology, Humans, Magnetic Resonance Imaging, Male
Pubmed
Web of science
Création de la notice
21/02/2019 10:04
Dernière modification de la notice
20/08/2019 12:56
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