The effects of sevoflurane and halothane anesthesia on cerebral blood flow velocity in children.

Détails

ID Serval
serval:BIB_209F5A3C69F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The effects of sevoflurane and halothane anesthesia on cerebral blood flow velocity in children.
Périodique
Anesthesia and analgesia
Auteur⸱e⸱s
Mönkhoff M., Schwarz U., Gerber A., Fanconi S., Bänziger O.
ISSN
0003-2999
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
92
Numéro
4
Pages
891-6
Langue
anglais
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
We compared cerebral blood flow velocity during anesthesia with sevoflurane and halothane in 23 children admitted for elective surgery (age, 0.4-9.7 yr; median age, 1.9 yr; ASA physical status I-II). Inhaled induction was performed in a randomized sequence with sevoflurane or halothane. Under steady-state conditions, cerebral blood flow velocity (systolic [V(s)], mean [V(mn)], and diastolic [VD]) were measured by a blinded investigator using transcranial pulsed Doppler ultrasonography. The anesthetic was then changed. CBFV measurements were repeated after washout of the first anesthetic and after steady-state of the second (equivalent minimal alveolar concentration to first anesthetic). The resistance index was calculated. VD and V(mn) were significantly lower during sevoflurane (V(mn) 1.35 m/s) than during halothane (V(mn) 1.50 m/s; P = 0.001), whereas V(s) was unchanged. The resistance index was lower during halothane (P < 0.001). Our results indicate lower vessel resistance and higher mean velocity during halothane than during sevoflurane. IMPLICATIONS: The mean cerebral blood flow velocity is significantly decreased in children during inhaled anesthesia with sevoflurane than during halothane. This might be relevant for the choice of anesthetic in children with risk of increased intracranial pressure, neurosurgery, or craniofacial osteotomies.
Mots-clé
Anesthetics, Inhalation, Cerebrovascular Circulation, Child, Child, Preschool, Cross-Over Studies, Female, Halothane, Hemodynamics, Humans, Infant, Male, Methyl Ethers, Middle Cerebral Artery, Preanesthetic Medication
Pubmed
Web of science
Création de la notice
25/01/2008 10:06
Dernière modification de la notice
20/08/2019 12:56
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