Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells.
Détails
ID Serval
serval:BIB_208EEDFA48B3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
101
Numéro
16
Pages
6116-6121
Langue
anglais
Résumé
CD8+ memory T cells have recently been recognized as playing a key role in natural immunity against unrelated viral infections, a phenomenon referred to as "heterologous antiviral immunity." We now provide data that the cellular immunological interactions that underlie such heterologous immunity can play an equally important role in regulating T helper 2 immune responses and protecting mucosal surfaces from allergen-induced inflammation. Our data show that CD8+ T cells, either retained in the lung after infection with influenza virus, or adoptively transferred via the intranasal route can suppress allergic airway inflammation. The suppression is mediated by IFN-gamma, which acts to reduce the activation level, T helper 2 cytokine production, airways hyperresponsiveness, and migration of allergen-specific CD4+ T cells into the lung, whereas the systemic and draining lymph node responses remain unchanged. Of note, adoptive transfer of previously activated transgenic CD8+ T cells conferred protection against allergic airway inflammation, even in the absence of specific-antigen. Airway resident CD8+ T cells produced IFN-gamma when directly exposed to conditioned media from activated dendritic cells or the proinflammatory cytokines IL-12 and IL-18. Taken together these data indicate that effector/memory CD8+ T cells present in the airways produce IFN-gamma after inflammatory stimuli, independent of specific-antigen, and as a consequence play a key role in modifying the degree and frequency of allergic responses in the lung.
Mots-clé
Adoptive Transfer, Animals, Bronchitis/immunology, Bronchoalveolar Lavage Fluid, Bystander Effect, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Culture Media, Conditioned, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Hypersensitivity/immunology, Immunologic Memory, Interferon-gamma/physiology, Lung/cytology, Lung/immunology, Lymphocyte Activation, Mice, Mice, Inbred C57BL
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/01/2010 17:09
Dernière modification de la notice
20/08/2019 13:56