Breath acetone to monitor life style interventions in field conditions: An exploratory study.

Détails

ID Serval
serval:BIB_20549DF806C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Breath acetone to monitor life style interventions in field conditions: An exploratory study.
Périodique
Obesity
Auteur⸱e⸱s
Samudrala D., Lammers G., Mandon J., Blanchet L., Schreuder T.H., Hopman M.T., Harren F.J., Tappy L., Cristescu S.M.
ISSN
1930-739X (Electronic)
ISSN-L
1930-7381
Statut éditorial
Publié
Date de publication
2014
Volume
22
Numéro
4
Pages
980-983
Langue
anglais
Notes
Publication types: Journal Article, pdf : Brief Cutting Edge Report
Résumé
OBJECTIVE: To assess whether breath acetone concentration can be used to monitor the effects of a prolonged physical activity on whole body lipolysis and hepatic ketogenesis in field conditions.
METHODS: Twenty-three non-diabetic, 11 type 1 diabetic, and 17 type 2 diabetic subjects provided breath and blood samples for this study. Samples were collected during the International Four Days Marches, in the Netherlands. For each participant, breath acetone concentration was measured using proton transfer reaction ion trap mass spectrometry, before and after a 30-50 km walk on four consecutive days. Blood non-esterified free fatty acid (NEFA), beta-hydroxybutyrate (BOHB), and glucose concentrations were measured after walking.
RESULTS: Breath acetone concentration was significantly higher after than before walking, and was positively correlated with blood NEFA and BOHB concentrations. The effect of walking on breath acetone concentration was repeatedly observed on all four consecutive days. Breath acetone concentrations were higher in type 1 diabetic subjects and lower in type 2 diabetic subjects than in control subjects.
CONCLUSIONS: Breath acetone can be used to monitor hepatic ketogenesis during walking under field conditions. It may, therefore, provide real-time information on fat burning, which may be of use for monitoring the lifestyle interventions.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/05/2014 18:49
Dernière modification de la notice
20/08/2019 13:56
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