Treatment of extraintestinal manifestations in inflammatory bowel disease.

Détails

ID Serval
serval:BIB_1F8686422B8F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Treatment of extraintestinal manifestations in inflammatory bowel disease.
Périodique
Digestion
Auteur⸱e⸱s
Lakatos P.L., Lakatos L., Kiss L.S., Peyrin-Biroulet L., Schoepfer A., Vavricka S.
ISSN
1421-9867 (Electronic)
ISSN-L
0012-2823
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
86
Numéro
Suppl 1
Pages
28-35
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Inflammatory bowel disease (IBD) is a systemic disease associated with a large number of extraintestinal manifestations (EIM). EIM are present in 15-20% of patients with ulcerative colitis and in 20-40% of patients with Crohn's disease. The management of EIM is best provided by a multidisciplinary team, which includes specialists in the affected organ systems with training in the treatment of IBD. Therapeutic strategy is often empirical. This is explained by the paucity of randomized-controlled studies for the specific treatment of EIM in IBD and by the fact that treatment models are based on extrapolation from patients with similar conditions but without IBD. For most EIM, the mainstay of therapy is the treatment of the underlying active IBD. However, some EIM such as axial arthritis, pyoderma gangrenosum, uveitis and primary sclerosing cholangitis run a clinical course independent of IBD activity and need specific therapy (e.g. TNF antagonists in ankylosing spondylitis and skin manifestations). This review summarizes the conventional and novel (e.g. anti-TNF) treatment modalities, and the therapeutic implications for the management of extraintestinal symptoms in IBD, in order to assist clinicians in optimizing treatment strategies for IBD patients with EIM.
Pubmed
Web of science
Création de la notice
08/11/2012 19:32
Dernière modification de la notice
20/08/2019 13:55
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