Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. I. Methodology.

Détails

ID Serval
serval:BIB_1F5D05908230
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. I. Methodology.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Gadian D.G., Frackowiak R.S., Crockard H.A., Proctor E., Allen K., Williams S.R., Russell R.W.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1987
Volume
7
Numéro
2
Pages
199-206
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with 1H and 31P nuclear magnetic resonance (NMR) spectroscopy. The NMR measurements were made with two surface coils, one on each hemisphere. This article describes the experimental details and shows that in acute unilateral or bilateral forebrain ischaemia metabolic changes can be monitored by NMR with no significant interhemispheric cross talk. The metabolic effects of reperfusion are also shown. The model allows the definition of the time course of the metabolic consequences of regional ischaemia and reperfusion in individual laboratory animals.
Mots-clé
Acute Disease, Animals, Brain Ischemia/physiopathology, Cerebrovascular Circulation, Energy Metabolism, Gerbillinae, Hydrogen/diagnostic use, Hydrogen/metabolism, Hydrogen-Ion Concentration, Lactates/analysis, Magnetic Resonance Spectroscopy, Male, Methods, Phosphorus/diagnostic use, Regional Blood Flow
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/10/2011 14:37
Dernière modification de la notice
20/08/2019 12:55
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