Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss.

Détails

ID Serval
serval:BIB_1F4736C5AACA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss.
Périodique
Modern Pathology
Auteur(s)
Clarke B., Tinker A.V., Lee C.H., Subramanian S., van de Rijn M., Turbin D., Kalloger S., Han G., Ceballos K., Cadungog M.G., Huntsman D.G., Coukos G., Gilks C.B.
ISSN
1530-0285 (Electronic)
ISSN-L
0893-3952
Statut éditorial
Publié
Date de publication
2009
Volume
22
Numéro
3
Pages
393-402
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Intraepithelial tumor-infiltrating T cells have been correlated with improved outcomes in ovarian carcinoma, however, it is not known whether there is an association with disease stage, histological subtype, or BRCA mutation/expression. Two case series of ovarian carcinomas were included in the study; a retrospective series of 500 patients, and 40 prospectively collected cases fully characterized for BRCA1 mutation status and expression. Intraepithelial immune cells were assessed as present or absent by immunohistochemical staining of tissue microarrays. In the retrospective case series, the presence of intraepithelial CD8(+) T-cells correlated with improved disease-specific survival (P=0.027), whereas intraepithelial CD3(+) T cells did not (P=0.49). For serous ovarian carcinomas, the presence of intraepithelial CD3(+) and CD8(+) T-cells correlated with improved disease-specific survival (P=0.0016 and P<or=0.0001, respectively). The presence of intraepithelial CD8(+) T cells was not associated with improved survival in endometrioid or clear cell carcinomas. On multivariate analysis, disease stage and CD8(+) T cells were found to be independently predictive of improved disease-specific survival, whereas grade, age at surgery, and type of adjuvant treatment were not. In the prospective patient cohort, intraepithelial CD8(+) T-cells correlated with the presence of mutation or loss of expression of BRCA1 through promoter methylation (P=0.019). Intraepithelial CD8(+) tumor-infiltrating T-cells correlate with improved clinical outcomes for all stages of ovarian cancer; this association is restricted to the serous ovarian cancer subtype, and is an independent prognostic factor on multivariate analysis. The presence of intraepithelial CD8(+) T cells also significantly correlates with loss of BRCA1.
Mots-clé
Adult, Aged, Aged, 80 and over, Antigens, CD3/immunology, Antigens, CD3/metabolism, CD8-Positive T-Lymphocytes/immunology, Female, Gene Expression, Genes, BRCA1, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Middle Aged, Mutation, Neoplasm Staging, Ovarian Neoplasms/genetics, Ovarian Neoplasms/immunology, Prognosis, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, Tissue Array Analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/10/2014 11:42
Dernière modification de la notice
20/08/2019 12:55
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