Urinary sphincter based on electronics and artificial muscles

Détails

ID Serval
serval:BIB_1F148EDEC465
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Urinary sphincter based on electronics and artificial muscles
Titre de la conférence
38th Congress of the European Society for Artificial Organs (ESAO 2011) and 4th Biennial Congress of the International Federation on Artificial Organs (IFAO 2011)
Auteur(s)
Valerio M., Tozzi P., Wieland M., Hayoz D., Mundy A.R., Jichlinski P.
Adresse
Porto, Portugal, October 9-12, 2011
ISBN
0391-3988
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
34
Série
International Journal of Artificial Organs
Pages
614
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Objectives: The AMS 800TM is the current artificial urinary sphincter (AUS) for incontinence due to intrinsic sphincter deficiency. Despite good clinical results, technical failures inherent to the hydraulic mechanism or urethral ischemic injury contribute to revisions up to 60%. We are developing an electronic AUS, called ARTUS to overcome the rigors of AMS. The objective of this study was to evaluate the technical efficacy and tissue tolerance of the ARTUS system in an animal model.Methods: The ARTUS is composed by three parts: the contractile unit, a series of rings and an integrated microprocessor. The contractile unit is made of Nitinol fibers. The rings are placed around the urethra to control the flow of urine by squeezing the urethra. They work in a sequential alternative mode and are controlled by a microprocessor. In the first phase a three-rings device was used while in the second phase a two-rings ARTUS was used. The device was implanted in 14 sheep divided in two groups of six and eight animals for study purpose. The first group aimed at bladder leak point pressure (BLPP) measurement and validation of the animal model; the second group aimed at verifying mid-term tissue tolerance by explants at twelve weeks. General animal tolerance was also evaluated.Results: The ARTUS system implantation was uneventful. When the system was activated, the BLPP was measured at 1.038±0.044 bar (mean±SD). Urethral tissue analysis did not show significant morphological changes. No infection and no sign of discomfort were noted in animals at 12 weeks.Conclusions: The ARTUS proved to be effective in continence achievement in this study. Histological results support our idea that a sequential alternative mode can avoid urethral atrophy and ischemia. Further technical developments are needed to verify long-term outcome and permit human use.
Mots-clé
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Web of science
Création de la notice
17/02/2012 10:40
Dernière modification de la notice
20/08/2019 12:55
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