Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study.

Détails

Ressource 1Télécharger: BIB_1F049CF968BF.P001.pdf (530.04 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_1F049CF968BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study.
Périodique
Plos Medicine
Auteur⸱e⸱s
Stringhini S., Batty G.D., Bovet P., Shipley M.J., Marmot M.G., Kumari M., Tabak A.G., Kivimäki M.
ISSN
1549-1676 (Electronic)
ISSN-L
1549-1277
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
10
Numéro
7
Pages
e1001479
Langue
anglais
Notes
Publication types: Journal Article
Résumé
BACKGROUND: Socioeconomic adversity in early life has been hypothesized to "program" a vulnerable phenotype with exaggerated inflammatory responses, so increasing the risk of developing type 2 diabetes in adulthood. The aim of this study is to test this hypothesis by assessing the extent to which the association between lifecourse socioeconomic status and type 2 diabetes incidence is explained by chronic inflammation.
METHODS AND FINDINGS: We use data from the British Whitehall II study, a prospective occupational cohort of adults established in 1985. The inflammatory markers C-reactive protein and interleukin-6 were measured repeatedly and type 2 diabetes incidence (new cases) was monitored over an 18-year follow-up (from 1991-1993 until 2007-2009). Our analytical sample consisted of 6,387 non-diabetic participants (1,818 women), of whom 731 (207 women) developed type 2 diabetes over the follow-up. Cumulative exposure to low socioeconomic status from childhood to middle age was associated with an increased risk of developing type 2 diabetes in adulthood (hazard ratio [HR] = 1.96, 95% confidence interval: 1.48-2.58 for low cumulative lifecourse socioeconomic score and HR = 1.55, 95% confidence interval: 1.26-1.91 for low-low socioeconomic trajectory). 25% of the excess risk associated with cumulative socioeconomic adversity across the lifecourse and 32% of the excess risk associated with low-low socioeconomic trajectory was attributable to chronically elevated inflammation (95% confidence intervals 16%-58%).
CONCLUSIONS: In the present study, chronic inflammation explained a substantial part of the association between lifecourse socioeconomic disadvantage and type 2 diabetes. Further studies should be performed to confirm these findings in population-based samples, as the Whitehall II cohort is not representative of the general population, and to examine the extent to which social inequalities attributable to chronic inflammation are reversible. Please see later in the article for the Editors' Summary.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/08/2013 16:28
Dernière modification de la notice
20/08/2019 12:55
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