Intraoral malignant melanotic schwannoma. Ultrastructural evidence for melanogenesis by Schwann's cells.

Détails

ID Serval
serval:BIB_1EFFF5ECBD2E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intraoral malignant melanotic schwannoma. Ultrastructural evidence for melanogenesis by Schwann's cells.
Périodique
Archives of Pathology and Laboratory Medicine
Auteur⸱e⸱s
Janzer R.C., Makek M.
ISSN
0003-9985[print], 0003-9985[linking]
Statut éditorial
Publié
Date de publication
1983
Volume
107
Numéro
6
Pages
298-301
Langue
anglais
Résumé
Clinical and light and electron microscopic findings of one case of malignant melanotic schwannoma of the oral cavity are presented. The tumor recurred four times and developed submandibular metastasis. At autopsy, 24 months after manifestation of the initial symptoms, a hematogenous metastatic nodule was present in the liver. Peripheral melanotic schwannomas show a more malignant behavior than intraspinal examples. The Schwann's cell character of the individual tumor cells is demonstrated ultrastructurally by the presence of a prominent basal lamina, desmosomelike junctions between interdigitated elongated cell processes, and melanosomes in all stages of formation. These findings support the concept that neoplastic human Schwann's cells are capable of melanogenesis.
Mots-clé
Female, Humans, Lymphatic Metastasis, Melanocytes/ultrastructure, Melanoma/ultrastructure, Middle Aged, Neurilemmoma/ultrastructure, Palatal Neoplasms/ultrastructure
Pubmed
Création de la notice
21/10/2010 8:39
Dernière modification de la notice
20/08/2019 12:55
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