Epineurial adipocytes are dispensable for Schwann cell myelination.

Détails

ID Serval
serval:BIB_1EE5CCE1AF03
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Epineurial adipocytes are dispensable for Schwann cell myelination.
Périodique
Journal of Neurochemistry
Auteur(s)
Nadra K., Médard J.J., Quignodon L., Verheijen M.H., Desvergne B., Chrast R.
ISSN
1471-4159 (Electronic)
ISSN-L
0022-3042
Statut éditorial
Publié
Date de publication
2012
Volume
123
Numéro
5
Pages
662-667
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Previous clinical observations and data from mouse models with defects in lipid metabolism suggested that epineurial adipocytes may play a role in peripheral nervous system myelination. We have used adipocyte-specific Lpin1 knockout mice to characterize the consequences of the presence of impaired epineurial adipocytes on the myelinating peripheral nerve. Our data revealed that the capacity of Schwann cells to establish myelin, and the functional properties of peripheral nerves, were not affected by compromised epineurial adipocytes in adipocyte-specific Lpin1 knockout mice. To evaluate the possibility that Lpin1-negative adipocytes are still able to support endoneurial Schwann cells, we also characterized sciatic nerves from mice carrying epiblast-specific deletion of peroxisome proliferator-activated receptor gamma, which develop general lipoatrophy. Interestingly, even the complete loss of adipocytes in the epineurium of peroxisome proliferator-activated receptor gamma knockout mice did not lead to detectable defects in Schwann cell myelination. However, probably as a consequence of their hyperglycemia, these mice have reduced nerve conduction velocity, thus mimicking the phenotype observed under diabetic condition. Together, our data indicate that while adipocytes, as regulators of lipid and glucose homeostasis, play a role in nerve function, their presence in epineurium is not essential for establishment or maintenance of proper myelin.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2012 18:30
Dernière modification de la notice
20/08/2019 12:54
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