In vivo testing of a novel adjustable glaucoma drainage device.

Détails

Ressource 1Télécharger: BIB_1E5B4D25FC31.P001.pdf (440.40 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_1E5B4D25FC31
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo testing of a novel adjustable glaucoma drainage device.
Périodique
Investigative Ophthalmology and Visual Science
Auteur⸱e⸱s
Villamarin A., Stergiopulos N., Bigler S., Mermoud A., Moulin A., Roy S.
ISSN
1552-5783 (Electronic)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
55
Numéro
11
Pages
7520-7524
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
PURPOSE: We report on the in vivo testing of a novel noninvasively adjustable glaucoma drainage device (AGDD), which features an adjustable outflow resistance, and assess the safety and efficiency of this implant.
METHODS: Under general anesthesia, the AGDD was implanted on seven white New Zealand rabbits for a duration of 4 months under a scleral flap in a way analogous to the Ex-PRESS device and set in an operationally closed position. The IOP was measured on a regular basis on the operated and control eyes using a rebound tonometer. Once a month the AGDD was adjusted noninvasively from its fully closed to its fully open position and the resulting pressure drop was measured. The contralateral eye was not operated and served as control. After euthanization, the eyes were collected for histology evaluation.
RESULTS: The mean preoperative IOP was 11.1 ± 2.4 mm Hg. The IOP was significantly lower for the operated eye (6.8 ± 2 mm Hg) compared to the nonoperated eye (13.1 ± 1.6 mm Hg) during the first 8 days after surgery. When opening the AGDD from its fully closed to fully open position, the IOP dropped significantly from 11.2 ± 2.9 to 4.8 ± 0.9 mm Hg (P < 0.05).
CONCLUSIONS: Implanting the AGDD is a safe and uncomplicated surgical procedure. The fluidic resistance was noninvasively adjustable during the postoperative period with the AGDD between its fully closed and fully open positions.
Mots-clé
Animals, Anterior Chamber/surgery, Disease Models, Animal, Follow-Up Studies, Glaucoma Drainage Implants, Glaucoma, Open-Angle/physiopathology, Glaucoma, Open-Angle/surgery, Intraocular Pressure, Prosthesis Design, Prosthesis Implantation, Rabbits, Trabeculectomy/methods
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/02/2015 17:56
Dernière modification de la notice
20/08/2019 12:54
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