Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation.

Détails

ID Serval
serval:BIB_1E5412805627
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation.
Périodique
Journal of Neurophysiology
Auteur(s)
Kew J.J., Ridding M.C., Rothwell J.C., Passingham R.E., Leigh P.N., Sooriakumaran S., Frackowiak R.S., Brooks D.J.
ISSN
0022-3077 (Print)
ISSN-L
0022-3077
Statut éditorial
Publié
Date de publication
1994
Volume
72
Numéro
5
Pages
2517-2524
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
1. Two complimentary techniques were used to study cortical function in six human upper limb amputees: positron emission tomographic (PET) measurements of regional cerebral blood flow (rCBF) were made in subjects during limb movements to study activation of the primary motor (M1), primary somatosensory (S1), and association cortices; and electromyographic responses to transcranial magnetic stimulation (TMS) were measured in proximal upper limb muscles to assess the excitability of corticospinal neurons in subjects at rest. 2. To explore possible cortical mechanisms governing the phantom limb phenomenon, PET and TMS findings were compared between subjects with acquired, traumatic upper limb amputations (n = 3), in whom phantom limb symptoms were prominent, and congenital upper limb amputees (n = 3) without phantom limbs. 3. Paced shoulder movements were associated with significant blood flow increases in the contralateral M1/S1 cortex of both groups of amputees. In traumatic amputees, these increases were present over a wider area and were of significantly greater magnitude in the partially deafferented cortex contralateral to the amputation. In congenital amputees blood flow increases were also present over a wider area in the partially deafferented M1/S1 cortex, but their magnitude was not significantly different from that in the normally afferented M1/S1 cortex. 4. Abnormal blood flow increases also were present in the partially deafferented M1/S1 cortex of traumatic amputees during movement of the ipsilateral, intact arm. Abnormal ipsilateral M1/S1 responses were not present during movement of the intact arm in the congenital group. 5. TMS studies showed that the abnormal blood flow increases in the partially deafferented M1 cortex of traumatic amputees were associated with increased corticospinal excitability.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adult, Afferent Pathways/blood supply, Afferent Pathways/radionuclide imaging, Amputation, Arm/innervation, Blood Flow Velocity/physiology, Brain Mapping, Cerebral Cortex/blood supply, Cerebral Cortex/radionuclide imaging, Ectromelia/physiopathology, Ectromelia/radionuclide imaging, Electromagnetic Fields, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Motor Cortex/blood supply, Motor Cortex/radionuclide imaging, Nerve Regeneration/physiology, Neural Inhibition/physiology, Neuronal Plasticity/physiology, Parietal Lobe/blood supply, Parietal Lobe/radionuclide imaging, Phantom Limb/physiopathology, Phantom Limb/radionuclide imaging, Regional Blood Flow/physiology, Somatosensory Cortex/blood supply, Somatosensory Cortex/radionuclide imaging, Synaptic Transmission, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
16/09/2011 20:34
Dernière modification de la notice
20/08/2019 12:54
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