Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

Détails

ID Serval
serval:BIB_1E48E0DD5B85
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Périodique
Lancet Infectious Diseases
Auteur(s)
Sanglard  D., Odds  F. C.
ISSN
1473-3099 (Print)
Statut éditorial
Publié
Date de publication
02/2002
Volume
2
Numéro
2
Pages
73-85
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Résumé
Candida albicans and related species pathogenic for man become resistant to antifungal agents, in particular triazole compounds, by expression of efflux pumps that reduce drug accumulation, alteration of the structure or concentration of antifungal target proteins, and alteration of membrane sterol composition. The clinical consequences of antifungal resistance can be seen in treatment failures in patients and in changes in the prevalences of Candida species causing disease. These effects were seen unequivocally in HIV-infected patients with oropharyngeal candida infections, but their incidence has decreased dramatically with the introduction of highly active antiretroviral therapy. The evidence for similar emergence of antifungal-resistant yeast strains and species in other types of candida infections is confounded by non-standardised susceptibility testing methods and definitions of a resistant fungal isolate. Recent large-scale surveys of yeasts isolated from blood cultures, based on standardised methodology and resistance definitions, do not support the view that antifungal resistance in pathogenic yeasts constitutes a significant or growing therapeutic problem.
Mots-clé
Amphotericin B/pharmacology Antifungal Agents/*pharmacology Azoles/pharmacology Candida/*drug effects Candidiasis/*drug therapy Cytochrome P-450 Enzyme System/genetics Drug Resistance, Fungal/*genetics Flucytosine/pharmacology Fungemia/drug therapy/microbiology Humans Microbial Sensitivity Tests Oxidoreductases/genetics Triazoles/pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 14:40
Dernière modification de la notice
20/08/2019 12:54
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