Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces.

Détails

ID Serval
serval:BIB_1E0FD84C06FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces.
Périodique
ACS applied materials & interfaces
Auteur⸱e⸱s
Karami P., Wyss C.S., Khoushabi A., Schmocker A., Broome M., Moser C., Bourban P.E., Pioletti D.P.
ISSN
1944-8252 (Electronic)
ISSN-L
1944-8244
Statut éditorial
Publié
Date de publication
14/11/2018
Peer-reviewed
Oui
Volume
10
Numéro
45
Pages
38692-38699
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite double-network hydrogel with ∼90% water content, which creates a dissipative interface and robustly adheres to soft tissues such as cartilage and meniscus. A double-network matrix composed of covalently cross-linked poly(ethylene glycol) dimethacrylate and ionically cross-linked alginate was reinforced with nanofibrillated cellulose. No tissue surface modification was needed to obtain high adhesion properties of the developed hydrogel. Instead, mechanistic principles were used to control interfacial crack propagation. Comparing to commercial tissue adhesives, the integration of the dissipative polymeric network on the soft tissue surfaces allowed a significant increase in the adhesion strength, such as ∼130 kPa for articular cartilage. Our findings highlight the significant role of controlling hydrogel structure and dissipation processes for toughening the interface. This research provides a promising path to the development of highly adhesive hydrogels for tissues repair.
Mots-clé
Alginates/chemistry, Alginates/pharmacology, Animals, Bone and Bones/drug effects, Cartilage/drug effects, Cattle, Cellulose/chemistry, Cellulose/pharmacology, Hydrogels/chemistry, Hydrogels/pharmacology, Meniscus/drug effects, Methacrylates/chemistry, Methacrylates/pharmacology, Nanostructures/chemistry, Polyethylene Glycols/chemistry, Polyethylene Glycols/pharmacology, Tissue Adhesives/chemistry, Tissue Adhesives/pharmacology, adhesion, biological surfaces, biomaterial, composite double-network hydrogel, tough interface
Pubmed
Web of science
Création de la notice
07/11/2018 13:17
Dernière modification de la notice
20/08/2019 13:54
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