Postprandial hepatic glycogen synthesis in liver transplant recipients

Détails

ID Serval
serval:BIB_1DC7CC1BC917
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Postprandial hepatic glycogen synthesis in liver transplant recipients
Périodique
Transplantation
Auteur(s)
Schneiter  P., Gillet  M., Chiolero  R., Wauters  J. P., Berger  M., Tappy  L.
ISSN
0041-1337 (Print)
Statut éditorial
Publié
Date de publication
03/2000
Volume
69
Numéro
5
Pages
978-81
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 15
Résumé
BACKGROUND: The liver plays a central role in glucose homeostasis by releasing glucose in the fasting state and by taking up and converting into glycogen part of the glucose absorbed from the gastrointestinal tract after meal ingestion. METHODS: To determine whether the hepatic denervation that accompanies liver transplantation interferes with these functions, we assessed glucose tolerance to an oral glucose load in seven patients at 2-6 weeks after orthotopic liver transplantation, in six patients after kidney transplantation, and in six healthy controls. Hepatic glycogen synthesis was non-invasively assessed over the 4 hours after ingestion of a glucose load by monitoring hepatic uridine diphosphoglucose turnover with 13C galactose and acetaminophen. RESULTS: Liver and kidney transplant recipients had increased postprandial glucose concentrations but normal hepatic uridine diphosphoglucose turnover, indicating an unaltered hepatic glycogen synthesis. CONCLUSIONS: These results indicate that denervated liver transplants have an adequate glucoregulatory function. Postprandial hyperglycemia in liver transplant recipients is therefore not due to alterations of liver glucose metabolism.
Mots-clé
Adult Blood Glucose/analysis Eating/*physiology Female Glycogen/*biosynthesis Humans Kidney Transplantation Liver/*metabolism *Liver Transplantation Male Middle Aged Postoperative Period Uridine Diphosphate Glucose/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:36
Dernière modification de la notice
20/08/2019 12:54
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