Adding diversity to ruthenium (II)-arene anticancer (RAPTA) compounds via click chemistry: the influence of hydrophobic chains

Détails

ID Serval
serval:BIB_1D8C541FD6C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Adding diversity to ruthenium (II)-arene anticancer (RAPTA) compounds via click chemistry: the influence of hydrophobic chains
Périodique
Journal of Organometallic Chemistry
Auteur(s)
Renfrew Anna K., Juillerat-Jeanneret L., Dyson Paul J.
ISSN
0022-328X
Statut éditorial
Publié
Date de publication
01/2011
Peer-reviewed
Oui
Volume
696
Pages
772-779
Langue
anglais
Résumé
The application of click chemistry to develop libraries of organometallic ruthenium-arene complexes with potential anticancer properties has been investigated. A series of ruthenium-imidazole-triazole complexes, with hydrophobic tails, were prepared from a common precursor via click chemistry. The tail could be attached to the ligand prior to coordination to the ruthenium complex were screened for cytotoxicity in tumourigenic and non-tumourigenic cell lines, and while the compounds were only moderately cytotoxic, good selectivity for tumourigenic cells were abserved.
Mots-clé
Bioorganometallic chemistry, anticancer drugs, click chemistry, metal-based drugs, bioinorganic chemistry
Web of science
Création de la notice
17/01/2011 12:04
Dernière modification de la notice
20/08/2019 13:53
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