Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.
Détails
ID Serval
serval:BIB_1D36A2DECF0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.
Périodique
Annals of Biomedical Engineering
ISSN
1521-6047[electronic], 0090-6964[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
38
Numéro
7
Pages
2398-2405
Langue
anglais
Résumé
Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7-15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2-5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92% of all stimulations. A cecal shortening of about 30% and an average intraluminal pressure increase of 10.0 +/- 6.0 mmHg were observed.
Mots-clé
Colon, Electrical Stimulation, Implantable Device, Pig, Microprocessor-Controlled Movement, Slow Waves, Entrainment, Motility, Transit, Model
Pubmed
Web of science
Création de la notice
01/07/2010 13:44
Dernière modification de la notice
20/08/2019 12:53