Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.

Détails

ID Serval
serval:BIB_1D36A2DECF0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Direct electrical stimulation using a battery-operated device for induction and modulation of colonic contractions in pigs.
Périodique
Annals of Biomedical Engineering
Auteur⸱e⸱s
Bertschi M., Schlageter V., Vesin J.M., Aellen S., Peloponissios N., D'Ambrogio A., Wiesel P.H., Givel J.C., Kucera P., Virag N.
ISSN
1521-6047[electronic], 0090-6964[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
38
Numéro
7
Pages
2398-2405
Langue
anglais
Résumé
Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum amplitude of 10 V). Three pairs of pacing electrodes were inserted into the cecal seromuscular layer of anesthetized pigs. During a first set of in vivo experiments conducted on six animals, a pacing protocol leading to cecum contractions was determined: stimulation bursts with 1 ms pulse width, 10 V amplitude (7-15 mA), 120 Hz frequency, and 30-s burst duration, repeated every 2-5 min. In a second testing phase, an evaluation of the pacing protocol was performed in four animals (120 stimulation bursts in total). By using the battery-operated stimulator, contractions of the cecum and movement of contents could be induced in 92% of all stimulations. A cecal shortening of about 30% and an average intraluminal pressure increase of 10.0 +/- 6.0 mmHg were observed.
Mots-clé
Colon, Electrical Stimulation, Implantable Device, Pig, Microprocessor-Controlled Movement, Slow Waves, Entrainment, Motility, Transit, Model
Pubmed
Web of science
Création de la notice
01/07/2010 13:44
Dernière modification de la notice
20/08/2019 12:53
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