Late biliary complications in human alveolar echinococcosis are associated with high mortality.

Détails

ID Serval
serval:BIB_1D28280CE172
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Late biliary complications in human alveolar echinococcosis are associated with high mortality.
Périodique
World Journal of Gastroenterology
Auteur⸱e⸱s
Frei P., Misselwitz B., Prakash M.K., Schoepfer A.M., Prinz Vavricka B.M., Müllhaupt B., Fried M., Lehmann K., Ammann R.W., Vavricka S.R.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
20
Numéro
19
Pages
5881-5888
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
AIM: To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis (AE) under long-term chemotherapy with benzimidazoles.
METHODS: Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE. We compared characteristics of patients with and without biliary complications, analyzed potential risk factor for biliary complications and performed survival analyses.
RESULTS: Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy, of which 26 (28%) patients developed late biliary complications. These patients had a median age of 55.5 (35.5-65) years at diagnosis of AE and developed biliary complications after 15 (8.25-19) years of chemotherapy. The most common biliary complications during long-term chemotherapy were late-onset cholangitis (n = 14), sclerosing cholangitis-like lesions (n = 8), hepatolithiasis (n = 5), affection of the common bile duct (n = 7) and secondary biliary cirrhosis (n = 7). Thirteen of the 26 patients had undergone surgery (including 12 resections) before chemotherapy. Previous surgery was a risk factor for late biliary complications in linear regression analysis (P = 0.012).
CONCLUSION: Late biliary complications can be observed in nearly one third of patients with non-resectable AE, with previous surgery being a potential risk factor. After the occurrence of late biliary complications, the median survival is only 3 years, suggesting that late biliary complications indicate a poor prognostic outcome.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/06/2014 18:28
Dernière modification de la notice
20/08/2019 13:53
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