Abstract: The COVID-19 pandemic and related restrictions have triggered simultaneous changes across multiple life domains within a very short timeframe. This major shock has seriously chal- lenged the ability of families to adapt to unanticipated changes over which they had little control. Switzerland instigated a low-intensity lockdown in response to COVID-19 in the spring of 2020. The resulting alterations to family life included changes to employment situations and working condi- tions (such as layoffs, temporary unemployment and home-based work) and the need to arrange home-schooling and childcare. This study examines how a sample of individuals with a trajectory of lone parenthood living in French-speaking Switzerland adapted their everyday lives to accommodate the shifting demands in the domains of employment and family responsibilities. Interviews were conducted between April and June 2020 for the longitudinal project “The multiple paths of lone parenthood”. Using this data, we analysed the COVID-related changes to work and family life, focusing on their time structuring. We found that parents who remained employed faced the greatest time pressures, although their experiences varied significantly depending on the adaptability of their work schedules, as well as the child(ren)’s age(s) and degree of autonomy. Home-based work and home-schooling resulted in more flexible schedules, although parents with the greatest work and family demands sought more time-structured organisation to facilitate their articulation. Social support was a crucial buffer for parents with conflicting demands across domains.