T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
Détails
ID Serval
serval:BIB_1BD2BD3C5F3A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
Périodique
European Journal of Immunology
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
08/1993
Volume
23
Numéro
8
Pages
1956-62
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
The fate of in vivo activated CD8+ cytotoxic T cells was studied in transgenic mice expressing a T cell receptor (TCR) specific for the lymphocytic choriomeningitis virus (LCMV) glycoprotein peptide 33-41 presented by major histocompatibility complex (MHC) class I molecules. LCMV infection of TCR transgenic mice induced LCMV-specific effector and memory T cells whereas injection of soluble LCMV glycoprotein peptide 33-41 resulted in tolerance by peripheral deletion and anergy of LCMV-specific T cells after an initial expansion phase. Similarly, LCMV peptide 33-41-specific tolerance could be achieved in normal C57BL/6 mice and was not abrogated by an LCMV infection. These results obtained with a classically MHC-restricted peptide antigen parallel previous findings with retroviral or bacterial superantigens and indicate a possibility to modulate specifically mature peripheral cytotoxic T lymphocytes in vivo.
Mots-clé
Animals
Cell Death
Cells, Cultured
Humans
*Immune Tolerance
Lymphocyte Depletion
Lymphocytic choriomeningitis virus/*immunology
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Transgenic
Peptide Fragments/immunology
Receptors, Antigen, T-Cell/genetics
T-Lymphocytes, Cytotoxic/*immunology/physiology
Viral Proteins/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
20/08/2019 13:52